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Collaborative Agreements (Details)
$ in Thousands
 1 Months Ended 12 Months Ended
Oct. 31, 2018
USD ($)
Nov. 30, 2013
USD ($)
market
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Collaborative Agreements          
Net product sales     $ 305,514 $ 260,886 $ 182,237
Deferred reimbursements     5,906 7,406  
Accrued expenses and other current liabilities     98,153 $ 96,841  
Collaborative Arrangements          
Collaborative Agreements          
Conditional aggregate payments per indication $ 88,000        
Discovery program fee $ 10,000        
Term of agreement 5 years        
Collaborative Arrangements | GSK          
Collaborative Agreements          
Payments for collaborative agreement     1,500    
Revised Agreement | GSK          
Collaborative Agreements          
Potential milestone payments upon achievement of post-approval and sales-based milestones   $ 40,000      
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones | market   8      
Net product sales     25,400    
Deferred reimbursements     7,400    
Accrued expenses and other current liabilities     $ 4,500