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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Warrants
Other Comprehensive Gain (Loss)
Accumulated Deficit
Balance (in shares) at Dec. 31, 2018   189,383,924        
Balance at Dec. 31, 2018 $ 342,912 $ 1,942 $ 1,740,061 $ 13,063 $ 68 $ (1,412,222)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares) 1,967,000 1,967,087        
Stock options exercised, net $ 11,476 $ 20 11,456      
Stock issued from equity financing (in shares)   18,720,930        
Stock issued from equity financing 188,994 $ 187 188,807      
Restricted stock tax vesting (in shares)   477,198        
Employee withholding taxes related to restricted stock unit vesting (3,235)   (3,235)      
Stock issued for contingent consideration (in shares)   771,804        
Stock issued for contingent consideration 9,316          
Stock-based compensation 44,430   44,430      
Warrants exercised (in shares)   101,787        
Warrants exercised 812 $ 1 1,487 (676)    
Equity component of the convertible notes (in shares)   43,995,139        
Equity component of the convertible notes 215,476          
Termination of capped call confirmations 19,875   19,875      
Unrealized holding gain on available-for-sale securities 467       467  
Foreign currency translation adjustment 2,290       2,290  
Net loss (356,388)         (356,388)
Balance (in shares) at Dec. 31, 2019   255,417,869        
Balance at Dec. 31, 2019 $ 476,425 $ 2,598 2,227,225 12,387 2,825 (1,768,610)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares) 5,243,000 5,233,672        
Stock options exercised, net $ 42,282 $ 52 42,230      
Restricted stock tax vesting (in shares)   1,411,920        
Employee withholding taxes related to restricted stock unit vesting (10,028)   (10,028)      
Stock-based compensation 49,151   49,151      
Unrealized holding gain on available-for-sale securities (225)       (225)  
Foreign currency translation adjustment 5,627       5,627  
Net loss $ (276,852)         (276,852)
Balance (in shares) at Dec. 31, 2020 262,063,461 262,063,461        
Balance at Dec. 31, 2020 $ 286,380 $ 2,650 2,308,578 12,387 8,227 (2,045,462)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares) 1,483,000 1,461,189        
Stock options exercised, net $ 10,228 $ 15 10,213      
Stock issued from equity financing 199,747 $ 112 199,552 83    
Restricted stock tax vesting (in shares)   1,064,135        
Employee withholding taxes related to restricted stock unit vesting (15,009)   (15,009)      
Stock-based compensation 57,838   57,838      
Warrants exercised (in shares)   2,554,999        
Warrants exercised 19,230 $ 26 31,591 (12,387)    
Equity component of the convertible notes 2,661          
Unrealized holding gain on available-for-sale securities (85)       (85)  
Foreign currency translation adjustment (3,161)       (3,161)  
Net loss $ (250,460)         (250,460)
Balance (in shares) at Dec. 31, 2021 278,912,800 278,912,800        
Balance at Dec. 31, 2021 $ 307,369 $ 2,808 $ 2,595,419 $ 83 $ 4,981 $ (2,295,922)