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Share-Based Compensation - Expense Summary (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense $ 12,463 $ 11,736 $ 43,114 $ 32,090
Research and development expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense 4,379 3,152 13,744 9,457
Selling, general, and administrative expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense $ 8,084 $ 8,584 $ 29,370 $ 22,633