<SEC-DOCUMENT>0001104659-22-070177.txt : 20220610
<SEC-HEADER>0001104659-22-070177.hdr.sgml : 20220610
<ACCEPTANCE-DATETIME>20220610164740
ACCESSION NUMBER:		0001104659-22-070177
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20220610
DATE AS OF CHANGE:		20220610
EFFECTIVENESS DATE:		20220610

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMICUS THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001178879
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				200422823
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-265531
		FILM NUMBER:		221009565

	BUSINESS ADDRESS:	
		STREET 1:		3675 MARKET STREET
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104
		BUSINESS PHONE:		(215) 921-7600

	MAIL ADDRESS:	
		STREET 1:		3675 MARKET STREET
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMICUS THERAPEUTICS INC
		DATE OF NAME CHANGE:	20020729
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>tm2218031d2_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
on June 10, 2022&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>File No. 333- &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, DC 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AMICUS THERAPEUTICS, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact Name of Registrant as Specified in Its
Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="vertical-align: top; width: 50%; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 49%; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>71-0869350</B></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or Other Jurisdiction of</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Incorporation or Organization)</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Identification No.)</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>3675 Market Street, Philadelphia, PA 19104<BR>
</B>(Address of Principal Executive Office)( Zip Code)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AMENDED AND RESTATED 2007 EQUITY INCENTIVE
PLAN<BR>
</B>(Full title of the plan)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>John F. Crowley<BR>
Chief Executive Officer<BR>
Amicus Therapeutics, Inc.<BR>
3675 Market Street</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Philadelphia, PA 19104</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and address of Agent for Service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(215) 921-7600<BR>
</B>(Telephone Number of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Copy to:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Scott R. Jones, Esquire<BR>
</B>Troutman Pepper Hamilton Sanders LLP<BR>
400 Berwyn Park<BR>
899 Cassatt Road<BR>
Berwyn, Pennsylvania 19312-1183<BR>
(610) 640-7800</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.
See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221;
and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; width: 51%; padding: 0.5pt 0.5pt 0.5pt 72.25pt"><FONT STYLE="font-size: 10pt">Large accelerated filer
    <FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 48%; padding: 0.5pt 72.25pt 0.5pt 0.5pt"><FONT STYLE="font-size: 10pt">Accelerated filer <FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.5pt 72.25pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer <FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 72.25pt 0.5pt 0.5pt"><FONT STYLE="font-size: 10pt">Smaller reporting company <FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 72.25pt 0.5pt 0.5pt"><FONT STYLE="font-size: 10pt">Emerging growth company <FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If an emerging growth company, indicate by check
mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. <FONT STYLE="font-family: Wingdings">&#168;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">This Registration Statement
on Form S-8 is being filed for the purpose of registering an additional 6,000,000 shares of Common Stock that were added to the shares
authorized for issuance under the Registrant&#8217;s Amended and Restated 2007 Equity Incentive Plan for which a Registration Statement
on Form S-8 relating to the same employee benefit plan is effective. Pursuant to General Instruction E to Form S-8, the contents of the
Registration Statements on Form S-8 (File Nos. 333-145305, 333-157219, 333-174900, 333-233153, 333-243779 and 333-257289) filed with
the Securities and Exchange Commission (the &#8220;Commission&#8221;) on <A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307011217/y37940sv8.htm" STYLE="-sec-extract: exhibit">August 10, 2007</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000089322009000251/w72683sv8.htm" STYLE="-sec-extract: exhibit">February 10, 2009</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012311059118/c18760sv8.htm" STYLE="-sec-extract: exhibit">June 15, 2011</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1s8.htm" STYLE="-sec-extract: exhibit">August 8, 2019</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465920092862/tm2026897d1_s8.htm" STYLE="-sec-extract: exhibit">August 11, 2020</A>, and <A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465921084168/tm2119601d2_s8.htm" STYLE="-sec-extract: exhibit">June 22, 2021</A>, respectively, are incorporated herein by reference except to the extent supplemented, amended
or superseded by the information set forth herein. Only those items of Form S-8 containing new information not contained in the earlier
registration statements are presented herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The following documents of
the Registrant filed with the Commission are incorporated by reference in this Registration Statement as of their respective dates:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">The Registrant&#8217;s <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000117887922000006/fold-20211231.htm" STYLE="-sec-extract: exhibit">Annual Report on Form 10-K for the fiscal year ended December 31, 2021, filed with the Commission on February 24, 2022;</A></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">The Registrant&#8217;s <A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000114036122015968/ny20002550x1_def14a.htm" STYLE="-sec-extract: exhibit">Definitive Proxy Statement on Schedule 14A, filed with the Commission on April 26, 2022;</A></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="font-size: 10pt">(c)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">The Registrant&#8217;s <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000117887922000011/fold-20220331.htm" STYLE="-sec-extract: exhibit">Quarterly Report on Form 10-Q for the quarter ended March 31, 2022 filed with the Commission on May 10, 2022;</A></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="font-size: 10pt">(d)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">The Registrant&#8217;s Current Reports on Form 8-K (other than portions
    thereof furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits accompanying such reports that are related to such items)
    filed on <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000110465922002472/tm222353d1_8k.htm" STYLE="-sec-extract: exhibit">January 10, 2022</A><U>,</U> <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000110465922026330/tm227309d2_8k.htm" STYLE="-sec-extract: exhibit">February 24, 2022</A>, <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1178879/000110465922058218/tm2215096d1_8k.htm" STYLE="-sec-extract: exhibit">May 10, 2022</A> and <A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000110465922070104/tm2218031d1_8k.htm" STYLE="-sec-extract: exhibit">June 10, 2022</A>; and</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="font-size: 10pt">(e)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">The <A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000117887920000015/exhibit48descriptionof.htm" STYLE="-sec-extract: exhibit">Description of the Registrant&#8217;s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934</A>, contained in Exhibit 4.8 to the Registrant&#8217;s Annual Report on Form 10-K
    for the fiscal year ended December 31, 2019, as filed with the Commission on March 2, 2020, which updates the description of the
    Registrant&#8217;s Common Stock contained in the Registrant&#8217;s registration statement on&nbsp;Form&nbsp;8-A&nbsp;dated May 23,
    2007, as amended by any subsequent amendment or report filed for the purpose of updating such description.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">All documents subsequently
filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents;
provided, however, that documents or information deemed to have been furnished and not filed in accordance with Commission rules shall
not be deemed incorporated by reference into this Registration Statement. Any statement contained herein or in a document, all or a portion
of which is incorporated or deemed to be incorporated by reference herein, shall be deemed to be modified or superseded for purposes
of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also
is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or amended, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. Exhibits.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 7%; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><B>Exhibit<BR>
    Number</B></FONT></TD>
    <TD STYLE="padding: 0.5pt; width: 2%">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; width: 6%">&nbsp;</TD>
    <TD STYLE="width: 2%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 83%; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000119312512085717/d299897dex31.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000119312512085717/d299897dex31.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(1)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000119312512085717/d299897dex31.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Restated Certificate of Incorporation of the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465915044580/a15-13880_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.2</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465915044580/a15-13880_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(2)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465915044580/a15-13880_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Certificate of Amendment to the Restated Certificate of Incorporation of
    the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465918039068/a18-15070_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.3</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465918039068/a18-15070_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(3)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465918039068/a18-15070_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Certificate of Amendment to the Restated Certificate of Incorporation of
    the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307006223/y32191a1exv3w4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.4</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307006223/y32191a1exv3w4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(4)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307006223/y32191a1exv3w4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Restated By-laws of the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307007596/y32191a2exv4w1.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.5</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307007596/y32191a2exv4w1.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(5)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307007596/y32191a2exv4w1.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Specimen Stock Certificate evidencing shares of common stock</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="tm2218031d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">5.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="tm2218031d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Opinion of Troutman Pepper Hamilton Sanders LLP</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="tm2218031d2_ex23-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">23.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="tm2218031d2_ex23-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting
    Firm</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="tm2218031d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">23.2</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="tm2218031d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Consent of Troutman Pepper Hamilton Sanders LLP (included in Exhibit 5.1)</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="#a_001"><FONT STYLE="font-size: 10pt">24.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="#a_001"><FONT STYLE="font-size: 10pt">Power of Attorney (included on the signature page)</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">99.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(6)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Amended and Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465916164572/a16-23950_1ex10d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">99.2</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465916164572/a16-23950_1ex10d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(7)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465916164572/a16-23950_1ex10d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Performance-Based Restricted Stock Unit Award Agreement under the
    Amended and Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="https://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofboardrestrictedstock.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">99.3</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="https://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofboardrestrictedstock.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(8)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="https://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofboardrestrictedstock.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Board Restricted Stock Unit Award Agreement under the Amended and
    Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofboardstockoptionawar.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">99.4</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofboardstockoptionawar.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(9)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofboardstockoptionawar.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Board Stock Option Award Agreement under the Amended and Restated
    2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofstockoptionawardagre.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">99.5</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofstockoptionawardagre.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(10)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887921000004/formofstockoptionawardagre.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Stock Option Award Agreement under the Amended and Restated 2007
    Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887922000006/fold-12312021xex1025.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">99.6</FONT></A></TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887922000006/fold-12312021xex1025.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(11)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/0001178879/000117887922000006/fold-12312021xex1025.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Restricted Stock Unit Award Agreement under the Amended and Restated
    2007 Equity Incentive Plan</FONT></A></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0%">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Annual Report on Form 10-K filed
    on February 28, 2012.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed
    on June 10, 2015.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed
    on June 8, 2018.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(4)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.4 to the Registrant&#8217;s Registration Statement on Form
    S-1/A (Registration No. 333-141700), as amended, originally filed with the Commission on April 27, 2007.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(5)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form
    S-1/A (Registration No. 333-141700), filed with the SEC on May 17, 2007.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(6)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit A to the Registrant&#8217;s Definitive Proxy Statement on
    Schedule 14A filed on April 26, 2022.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(7)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 10.1 to the Registrant&#8217;s Current Report on Form 8-K
    filed on December 30, 2016.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(8)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 10.39 to the Registrant&#8217;s Registration Annual Report
    on Form 10-K filed on March 1, 2021.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(9)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 10.41 to the Registrant&#8217;s Registration Annual Report
    on Form 10-K filed on March 1, 2021.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(10)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 10.42 to the Registrant&#8217;s Registration Annual Report
    on Form 10-K filed on March 1, 2021.</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(11)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 10.25 to the Registrant&#8217;s Registration Annual Report
    on Form 10-K filed on February 24, 2022.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the city of Philadelphia, Commonwealth of Pennsylvania, on the 10th day of June, 2022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">AMICUS THERAPEUTICS, INC.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt">/s/ John F. Crowley</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 3%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.5pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="width: 42%; padding: 0.5pt"><FONT STYLE="font-size: 10pt">John F. Crowley</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">Chairman and Chief Executive Officer</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="a_001"></A>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We, the undersigned officers
and directors of Amicus Therapeutics, Inc., hereby severally constitute and appoint John F. Crowley, Bradley L. Campbell, Daphne Quimi
and Ellen S. Rosenberg, and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign
for us and in our names in the capacities indicated below, the Registration Statement on Form S-8 filed herewith and any and all subsequent
amendments to said Registration Statement, and generally to do all such things in our names and on our behalf in our capacities as officers
and directors to enable Amicus Therapeutics, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all requirements
of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys,
or any of them, to said Registration Statement and any and all amendments thereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
of the Securities Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the following persons in the capacities
indicated on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 38%; border-bottom: black 1pt solid; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
    <TD STYLE="width: 2%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 32%; border-bottom: black 1pt solid; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
    <TD STYLE="width: 2%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 26%; border-bottom: black 1pt solid; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ John F. Crowley</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Chairman and Chief
    Executive Officer</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">John F. Crowley</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">(Principal Executive
    Officer)</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Daphne Quimi</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Chief Financial
    Officer</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Daphne Quimi</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">(Principal Financial
    Officer and <BR>
Principal Accounting Officer)</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Lynn D. Bleil</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Lynn D. Bleil</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Bradley L. Campbell</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Bradley L. Campbell</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Michael A. Kelly</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Michael A. Kelly</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Margaret G. McGlynn</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Margaret G. McGlynn</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Michael G. Raab</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Michael G. Raab</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>

<TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: Black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Eiry W. Roberts,
    M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt">Eiry W. Roberts, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Glenn P. Sblendorio</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Glenn P. Sblendorio</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Craig A. Wheeler</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Craig A. Wheeler</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Burke W. Whitman</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 10, 2022</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Burke W. Whitman</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  </TABLE>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>tm2218031d2_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

                           <P STYLE="margin: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 5.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
<TD STYLE="width: 50%; font-size: 10pt">&nbsp;</TD>
<TD ROWSPAN="5" STYLE="text-align: right; width: 50%; vertical-align: top"><IMG SRC="tm2218031d2_ex5-1img001.jpg" ALT=""></TD></TR>
<TR STYLE="vertical-align: bottom">
<TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Troutman Pepper Hamilton Sanders LLP</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
<TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">400 Berwyn Park, 899 Cassatt Road</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
<TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Berwyn, PA 19312-1183</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
<TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
<TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">troutman.com</FONT></TD>
<TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">June 10, 2022</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Amicus Therapeutics, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">3675 Market Street</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Philadelphia, PA 19104</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.2in">Re:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <U>Registration Statement on Form&nbsp;S-8</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">Reference is made to the
registration statement on Form&nbsp;S-8 (the &#8220;<B><I>Registration Statement</I></B>&#8221;) of Amicus Therapeutics, Inc., a Delaware
corporation (the &#8220;<B><I>Company</I></B>&#8221;), filed on the date hereof with the Securities and Exchange Commission (the &#8220;<B><I>Commission</I></B>&#8221;),
under the Securities Act of 1933, as amended (the &#8220;<B><I>Act</I></B>&#8221;).&nbsp; The Registration Statement covers an aggregate
of 6,000,000 shares (the &#8220;<B><I>Shares</I></B>&#8221;), of the Company&#8217;s common stock, par value $0.01 per share (&#8220;<B><I>Common
Stock</I></B>&#8221;) issuable pursuant to the Company&#8217;s Amended and Restated 2007 Equity Incentive Plan (as amended, the &#8220;<B><I>Plan</I></B>&#8221;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">For purposes of this opinion
letter, we have examined the Registration Statement, including the exhibits thereto, the originals or copies, certified or otherwise identified
to our satisfaction, of the Company&#8217;s Restated Certificate of Incorporation, as amended, the Company&#8217;s Restated Bylaws, the
Plan and such other agreements, instruments and documents as we have deemed appropriate in rendering this opinion.&nbsp; As to matters
of fact, we have relied on certain representations of officers of the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">In our examination of the
aforesaid documents and rendering this opinion, we have assumed the genuineness and authenticity of all signatures on original documents;
the legal capacity of all natural persons; the authenticity of all documents submitted to us as originals; the conformity to originals
of all documents submitted to us as certified or photocopies; the accuracy and completeness of all documents and records reviewed by us;
the accuracy, completeness and authenticity of certificates issued by any governmental official, office or agency and the absence of change
in the information contained therein from the effective date of any such certificate; and the due authorization, execution and delivery
of all documents where authorization, execution and delivery are prerequisites to the effectiveness of such documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 27pt">This opinion letter is based
as to matters of law solely on the General Corporation Law of the State of Delaware, as amended. We express no opinion herein as to any
other statutes, rules or regulations. We assume no obligation to supplement this opinion if any applicable law changes after the date
hereof or if we become aware of any fact that might change the opinion expressed herein after the date hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">Based on, subject to and
limited by the foregoing, we are of the opinion that, following the (i) effectiveness of the Registration Statement, (ii) issuance of
the Shares in accordance with the terms of the Plan and (iii) receipt by the Company of the consideration for the Shares specified in
the applicable resolutions of the Board of Directors or a duly authorized committee thereof, the Plan or any underlying award agreements
or letters, the Shares will be validly issued, fully paid and non-assessable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

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<TR STYLE="vertical-align: top">
  <TD STYLE="text-align: justify; width: 30%">&nbsp;</TD>
  <TD STYLE="text-align: right; width: 50%"><IMG SRC="tm2218031d2_ex5-1img002.jpg" ALT=""></TD></TR>
<TR STYLE="vertical-align: top">
  <TD STYLE="border-bottom: Black 1pt solid; text-align: justify">&nbsp;</TD>
  <TD STYLE="border-bottom: Black 1pt solid; text-align: justify">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">This opinion letter has
been prepared for use in connection with the Registration Statement. This opinion letter is given as of the date hereof, and we
express no opinion as to the effect of subsequent events or changes in law occurring or becoming effective after the date hereof. We
assume no obligation to update this opinion letter or otherwise advise you with respect to any facts or circumstances or changes in
law that may hereafter occur or come to our attention.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">We hereby consent to the
filing of this opinion as an exhibit to the Registration Statement.&nbsp; In giving such consent, we do not thereby admit that we come
within the category of persons whose consent is required under Section&nbsp;7 of the Act or the rules&nbsp;or regulations of the Commission
thereunder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 50%"><FONT STYLE="font-size: 10pt">Very truly yours,</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">/s/ Troutman Pepper Hamilton Sanders LLP</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Troutman Pepper Hamilton Sanders LLP</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>tm2218031d2_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
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</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

                           <P STYLE="margin: 0pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 23.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING
FIRM</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We consent to the incorporation by reference in
this Registration Statement (Form S-8) pertaining to the Amended and Restated 2007 Equity Incentive Plan of Amicus Therapeutics, Inc.,
of our reports dated February 24, 2022, with respect to the consolidated financial statements of Amicus Therapeutics, Inc., and the effectiveness
of internal control over financial reporting of Amicus Therapeutics, Inc., included in its Annual Report (Form 10-K) for the year ended
December 31, 2021, filed with the Securities and Exchange Commission.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">/s/ Ernst &amp; Young LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Iselin, New Jersey</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">June 10, 2022</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>



<P STYLE="margin: 0pt">&nbsp;</P>

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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>tm2218031d2_ex-filingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
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                           <P STYLE="margin: 0pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 107.1 </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Calculation of Filing Fee Table </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Form S-8</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Form Type)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Amicus Therapeutics, Inc. &nbsp;</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Exact Name of Registrant as Specified in its
Charter)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>Table 1: Newly Registered Securities</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; border-bottom: Black 1pt solid">Security<BR> Type</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Security Class Title</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Fee<BR> Calculation<BR> Rule</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Amount<BR> Registered(1)</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Proposed<BR> Maximum<BR> Offering<BR> Price Per<BR> Unit</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Maximum<BR> Aggregate Offering<BR> Price</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Fee Rate</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Amount of<BR> Registration<BR> Fee</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; width: 10%; font-size: 10pt; vertical-align: top">Equity</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 17%; font-size: 10pt; text-align: left">Common Stock, $0.01 par value per share, reserved for issuance pursuant to the Amended and Restated 2007 Equity Incentive Plan</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; font-size: 10pt; text-align: right">457(h)</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left"></TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; font-size: 10pt; text-align: right">6,000,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt">$</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; font-size: 10pt; text-align: right">8.05<FONT STYLE="font-size: 10pt">(2)</FONT></TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt">$</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; font-size: 10pt; text-align: right">48,300,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; font-size: 10pt; text-align: right">0.0000927</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt">$</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; font-size: 10pt; text-align: right">4,477.41</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Total Offering Amounts</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">$</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="vertical-align: bottom; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">48,300,000</FONT></TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">$</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4,477.41</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Total Fee Offsets</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&mdash;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Net Fee Due</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">$</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4,477.41</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; font-size: 10pt"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="text-align: justify; font-size: 10pt"><FONT STYLE="font-size: 10pt">Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), this Registration Statement shall also cover any additional shares of the Registrant&#8217;s common stock that become issuable under the Amended and Restated 2007 Equity Incentive Plan (the &#8220;Plan&#8221;) by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of the Registrant&#8217;s outstanding shares of common stock. </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; font-size: 10pt"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="text-align: justify; font-size: 10pt"><FONT STYLE="font-size: 10pt">Estimated in accordance with Rule 457(h)(1) under the Securities Act solely for purposes of calculating the registration fee, based on the average of the high and low sales prices for the common stock as reported on the NASDAQ Global Market on June 6, 2022. </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>tm2218031d2_ex5-1img001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
