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Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Warrants | Other Comprehensive Gain (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2019 |  | 255,417,869 |  |  |  |
Balance at Dec. 31, 2019 | $ 476,425 | $ 2,598 | $ 2,227,225 | $ 12,387 | $ 2,825 | $ (1,768,610)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock options exercised, net (in shares) | 5,243,000 | 5,233,672 |  |  |  |
Stock options exercised, net | $ 42,282 | $ 52 | 42,230 |  |  |
Vesting of restricted stock units, net of taxes (in shares) |  | 1,411,920 |  |  |  |
Vesting of restricted stock units, net of taxes | (10,028) |  | (10,028) |  |  |
Share-based compensation | 49,151 |  | 49,151 |  |  |
Unrealized gain (loss) on available-for-sale securities | (225) |  |  |  | (225) |
Foreign currency translation adjustment | 5,627 |  |  |  | 5,627 |
Net loss | (276,852) |  |  |  |  | (276,852)
Balance (in shares) at Dec. 31, 2020 |  | 262,063,461 |  |  |  |
Balance at Dec. 31, 2020 | $ 286,380 | $ 2,650 | 2,308,578 | 12,387 | 8,227 | (2,045,462)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock options exercised, net (in shares) | 1,483,000 | 1,461,189 |  |  |  |
Stock options exercised, net | $ 10,228 | $ 15 | 10,213 |  |  |
Common stock issued from equity financing and pre-funded warrants (in shares) |  | 11,296,660 |  |  |  |
Common stock issued from equity financing and pre-funded warrants | 199,747 | $ 112 | 199,552 | 83 |  |
Vesting of restricted stock units, net of taxes (in shares) |  | 1,064,135 |  |  |  |
Vesting of restricted stock units, net of taxes | (15,009) |  | (15,009) |  |  |
Share-based compensation | 57,838 |  | 57,838 |  |  |
Warrants exercised (in shares) |  | 2,554,999 |  |  |  |
Warrants exercised | 19,230 | $ 26 | 31,591 | (12,387) |  |
Equity component of the convertible notes | 2,661 | $ 5 | 2,656 |  |  |
Unrealized gain (loss) on available-for-sale securities | (85) |  |  |  | (85) |
Foreign currency translation adjustment | (3,161) |  |  |  | (3,161) |
Net loss | $ (250,460) |  |  |  |  | (250,460)
Balance (in shares) at Dec. 31, 2021 | 278,912,800 | 278,912,800 |  |  |  |
Balance at Dec. 31, 2021 | $ 307,369 | $ 2,808 | 2,595,419 | 83 | 4,981 | (2,295,922)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock options exercised, net (in shares) | 660,000 | 656,377 |  |  |  |
Stock options exercised, net | $ 4,310 | $ 7 | 4,303 |  |  |
Vesting of restricted stock units, net of taxes (in shares) |  | 1,539,096 |  |  |  |
Vesting of restricted stock units, net of taxes | (11,490) |  | (11,490) |  |  |
Share-based compensation | 76,512 |  | 76,512 |  |  |
Unrealized gain (loss) on available-for-sale securities | 154 |  |  |  | 154 |
Foreign currency translation adjustment | (17,240) |  |  |  | (17,240) |
Net loss | $ (236,568) |  |  |  |  | (236,568)
Balance (in shares) at Dec. 31, 2022 | 281,108,273 | 281,108,273 |  |  |  |
Balance at Dec. 31, 2022 | $ 123,047 | $ 2,815 | $ 2,664,744 | $ 83 | $ (12,105) | $ (2,532,490)

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