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Summary of Significant Accounting Policies - Concentration of Credit Risk and Revenue Recognition (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Concentration Risk [Line Items] |  |  |
Allowance for doubtful accounts receivable | $ 200 |  |
Net product sales | 329,233 | $ 305,514 | $ 260,886
Galafold |  |  |
Concentration Risk [Line Items] |  |  |
Net product sales | $ 329,000 | $ 305,500 | $ 260,900
Net product sales | Customer Concentration Risk | Customer One |  |  |
Concentration Risk [Line Items] |  |  |
Concentration risk, percentage | 27.00% | 24.00% |
Accounts receivable | Customer Concentration Risk | Customer One |  |  |
Concentration Risk [Line Items] |  |  |
Concentration risk, percentage | 14.00% | 14.00% |

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