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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Operating activities |  |  |
Net loss | $ (236,568,000) | $ (250,460,000) | $ (276,852,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Amortization of debt discount and deferred financing | 2,634,000 | 2,490,000 | 1,794,000
Depreciation and amortization | 5,342,000 | 6,209,000 | 8,846,000
Share-based compensation | 76,512,000 | 57,838,000 | 49,151,000
Loss on extinguishment of debt | 0 | 257,000 | 7,276,000
Non-cash changes in the fair value of contingent consideration payable | 1,078,000 | 6,514,000 | 3,144,000
Foreign currency remeasurement loss | 6,121,000 | 3,565,000 | 5,471,000
Non-cash deferred taxes | 9,000 | 34,000 | (155,000)
Asset impairment charges and other asset write-offs | 18,177,000 | 0 | 99,000
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (17,330,000) | (8,189,000) | (11,219,000)
Inventories | (5,343,000) | (7,790,000) | (4,639,000)
Prepaid expenses and other current assets | (6,194,000) | (5,919,000) | (8,766,000)
Accounts payable, accrued expenses, and other current liabilities | (6,377,000) | 7,430,000 | (10,610,000)
Other non-current assets and liabilities | (4,636,000) | (4,117,000) | 3,170,000
Payment of contingent consideration | 0 | (10,353,000) | 0
Net cash used in operating activities | (166,575,000) | (202,491,000) | (233,290,000)
Investing activities |  |  |
Sale and redemption of marketable securities | 335,926,000 | 424,043,000 | 354,826,000
Purchases of marketable securities | (243,255,000) | (341,398,000) | (365,178,000)
Capital expenditures | (3,766,000) | (3,884,000) | (3,227,000)
Proceeds from sale of assets | 3,411,000 | 0 | 0
Net cash provided by (used in) investing activities | 92,316,000 | 78,761,000 | (13,579,000)
Financing activities |  |  |
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs | 0 | 199,750,000 | 0
Payment of long-term debt | 0 | 0 | (155,249,000)
Proceeds from long-term debt, net of issuance costs | 0 | 0 | 385,929,000
Payment of finance leases | (283,000) | (479,000) | (76,000)
Purchase of vested restricted stock units, net of taxes | (11,490,000) | (15,009,000) | (10,028,000)
Proceeds from stock options exercised, net | 4,310,000 | 10,228,000 | 42,282,000
Proceeds from warrants exercised, net | 0 | 19,230,000 | 0
Payment of contingent consideration | 0 | (1,647,000) | 0
Net cash (used in) provided by financing activities | (7,463,000) | 212,073,000 | 262,858,000
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | (14,619,000) | (5,049,000) | 3,830,000
Net increase in cash, cash equivalents, and restricted cash | (96,341,000) | 83,294,000 | 19,819,000
Cash, cash equivalents, and restricted cash at the beginning of the year | 249,456,000 | 166,162,000 | 146,343,000
Cash, cash equivalents, and restricted cash at the end of the year | 153,115,000 | 249,456,000 | 166,162,000
Supplemental disclosures of cash flow information |  |  |
Tenant improvements paid through lease incentive | 0 | 300,000 | 470,000
Cash paid during the period for interest | 34,358,000 | 30,468,000 | 24,683,000
Capital expenditures unpaid at the end of period | 1,141,000 | 1,448,000 | 985,000
Cash paid for income taxes | $ 1,609,000 | $ 20,032,000 | $ 10,371,000

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