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Summary of Significant Accounting Policies - Revenue by Geographical Area (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Disaggregation of Revenue [Line Items]      
Net product sales $ 329,233 $ 305,514 $ 260,886
U.S.      
Disaggregation of Revenue [Line Items]      
Net product sales 115,946 95,387 80,046
Ex-U.S.      
Disaggregation of Revenue [Line Items]      
Net product sales $ 213,287 $ 210,127 $ 180,840