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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Statement [Abstract]      
Net product sales $ 329,233 $ 305,514 $ 260,886
Cost of goods sold 38,599 34,466 31,044
Gross profit 290,634 271,048 229,842
Operating expenses:      
Research and development 276,677 272,049 308,443
Selling, general, and administrative 213,041 192,710 156,407
Changes in fair value of contingent consideration payable 1,078 6,514 3,144
Loss on impairment of assets 6,616 0 0
Depreciation and amortization 5,342 6,209 8,846
Total operating expenses 502,754 477,482 476,840
Loss from operations (212,120) (206,434) (246,998)
Other income (expense):      
Interest income 3,024 509 3,226
Interest expense (37,119) (32,471) (22,425)
Loss on extinguishment of debt 0 (257) (7,276)
Other income (expense) 4,176 (2,901) (781)
Loss before income tax (242,039) (241,554) (274,254)
Income tax benefit (expense) 5,471 (8,906) (2,598)
Net loss attributable to common stockholders $ (236,568) $ (250,460) $ (276,852)
Net loss attributable to common stockholders per common share - basic (in dollars per share) $ (0.82) $ (0.92) $ (1.07)
Net loss attributable to common stockholders per common share - diluted (in dollars per share) $ (0.82) $ (0.92) $ (1.07)
Weighted-average common shares outstanding - basic (in shares) 289,057,198 271,421,986 258,867,380
Weighted-average common shares outstanding - diluted (in shares) 289,057,198 271,421,986 258,867,380