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Stockholders' Equity - Common Stock and Warrants (Details) $ / shares in Units, $ in Thousands	1 Months Ended		3 Months Ended		12 Months Ended
	Nov. 30, 2022 USD ($)	Sep. 30, 2021 USD ($) $ / shares shares	Sep. 30, 2021 USD ($) $ / shares shares	Mar. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) vote $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($)
Convertible Debt
Common stock, shares authorized (in shares) | shares					500,000,000	500,000,000
Voting right for each share held, number | vote					1
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs		$ 199,800			$ 0	$ 199,750	$ 0
Gross cash proceeds from warrant exercises				$ 19,200	$ 0	$ 19,230	$ 0
Common stock, par value (in dollars per share) | $ / shares		$ 0.01	$ 0.01		$ 0.01	$ 0.01
Equity component of the convertible notes						$ 2,661
2016 Convertible Notes | Convertible Notes
Convertible Debt
Debt conversion, converted instrument, amount			$ 2,800
At The Market Equity Program
Convertible Debt
Proceeds from issuance of common stock	$ 250,000
Private Placement
Convertible Debt
Stock issued (in dollars per share) | $ / shares		$ 10.18	$ 10.18
Number of common shares called by warrants (in shares) | shares		8,349,705	8,349,705
Exercise price of warrants (in dollars per share) | $ / shares		$ 0.01	$ 0.01
Stock Exercises at $7.98
Convertible Debt
Exercise price of warrants (in dollars per share) | $ / shares				$ 7.98
Stock Exercises at $7.06
Convertible Debt
Exercise price of warrants (in dollars per share) | $ / shares				$ 7.06
Common Stock
Convertible Debt
Stock issued from equity financing (in shares) | shares		11,296,660				11,296,660
Equity component of the convertible notes (in shares) | shares			472,356
Equity component of the convertible notes			$ 5			$ 5
Additional Paid-In Capital
Convertible Debt
Equity component of the convertible notes			$ 2,700			$ 2,656
Warrants | Private Placement
Convertible Debt
Stock issued (in dollars per share) | $ / shares		$ 10.17	$ 10.17
Warrants | Stock Exercises at $7.98
Convertible Debt
Stock issued from equity financing (in shares) | shares				1,294,999
Warrants | Stock Exercises at $7.06
Convertible Debt
Stock issued from equity financing (in shares) | shares				1,260,000

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