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Income Taxes - Deferred and Valuation (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Deferred tax assets    
Intellectual property $ 68,567 $ 105,453
Research tax credit 223,366 205,095
Capitalized research and development costs 29,317 0
Net operating loss carry forwards 315,444 334,762
Share-based compensation 16,417 11,779
Interest carry forward limitation 12,558 8,285
Lease liability 11,428 9,105
Inventory 10,400 0
Other 20,109 17,748
Gross deferred tax assets 707,606 692,227
Deferred tax liabilities    
Business acquisition (4,939) (4,930)
Royalty payable (68,567) (105,453)
Other (6,806) (4,932)
Total net deferred tax assets 627,294 576,912
Less: valuation allowance (632,233) (581,842)
Net deferred tax liability (4,939) (4,930)
Valuation allowance 632,233 $ 581,842
Increase in the valuation allowance $ (50,400)