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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Warrants
Other Comprehensive Gain (Loss)
Accumulated Deficit
Balance (in shares) at Dec. 31, 2019   255,417,869        
Balance at Dec. 31, 2019 $ 476,425 $ 2,598 $ 2,227,225 $ 12,387 $ 2,825 $ (1,768,610)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares) 5,243,000 5,233,672        
Stock options exercised, net $ 42,282 $ 52 42,230      
Vesting of restricted stock units, net of taxes (in shares)   1,411,920        
Vesting of restricted stock units, net of taxes (10,028)   (10,028)      
Share-based compensation 49,151   49,151      
Unrealized gain (loss) on available-for-sale securities (225)       (225)  
Foreign currency translation adjustment 5,627       5,627  
Net loss (276,852)         (276,852)
Balance (in shares) at Dec. 31, 2020   262,063,461        
Balance at Dec. 31, 2020 $ 286,380 $ 2,650 2,308,578 12,387 8,227 (2,045,462)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares) 1,483,000 1,461,189        
Stock options exercised, net $ 10,228 $ 15 10,213      
Common stock issued from equity financing and pre-funded warrants (in shares)   11,296,660        
Common stock issued from equity financing and pre-funded warrants 199,747 $ 112 199,552 83    
Vesting of restricted stock units, net of taxes (in shares)   1,064,135        
Vesting of restricted stock units, net of taxes (15,009)   (15,009)      
Share-based compensation 57,838   57,838      
Warrants exercised (in shares)   2,554,999        
Warrants exercised 19,230 $ 26 31,591 (12,387)    
Equity component of the convertible notes 2,661 $ 5 2,656      
Unrealized gain (loss) on available-for-sale securities (85)       (85)  
Foreign currency translation adjustment (3,161)       (3,161)  
Net loss $ (250,460)         (250,460)
Balance (in shares) at Dec. 31, 2021 278,912,800 278,912,800        
Balance at Dec. 31, 2021 $ 307,369 $ 2,808 2,595,419 83 4,981 (2,295,922)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares) 660,000 656,377        
Stock options exercised, net $ 4,310 $ 7 4,303      
Vesting of restricted stock units, net of taxes (in shares)   1,539,096        
Vesting of restricted stock units, net of taxes (11,490)   (11,490)      
Share-based compensation 76,512   76,512      
Unrealized gain (loss) on available-for-sale securities 154       154  
Foreign currency translation adjustment (17,240)       (17,240)  
Net loss $ (236,568)         (236,568)
Balance (in shares) at Dec. 31, 2022 281,108,273 281,108,273        
Balance at Dec. 31, 2022 $ 123,047 $ 2,815 $ 2,664,744 $ 83 $ (12,105) $ (2,532,490)