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Income Taxes - Loss Carryforwards (Details) $ in Millions	Dec. 31, 2022 USD ($)
Research and experimentation tax credit carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	$ 36.4
Orphan drug tax credit carryforwards
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	187.0
Federal
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	1,183.0
State
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	$ 992.0

X

- Definition

Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32559-109319

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The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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