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Collaborative Agreements (Details)
$ in Thousands
 1 Months Ended 12 Months Ended
Dec. 31, 2022
USD ($)
Nov. 30, 2013
USD ($)
market
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Collaborative Agreements          
Net product sales     $ 329,233 $ 305,514 $ 260,886
Deferred reimbursements $ 4,656   4,656 5,906  
Accrued expenses and other current liabilities 93,636   93,636 $ 98,153  
Termination Agreement          
Collaborative Agreements          
Payments for collaborative agreement 23,700        
Collaborative Arrangements          
Collaborative Agreements          
Conditional aggregate payments per indication 86,500   86,500    
Revised Agreement | GSK          
Collaborative Agreements          
Potential milestone payments upon achievement of post-approval and sales-based milestones   $ 40,000      
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones | market   8      
Net product sales     25,100    
Deferred reimbursements 7,400   7,400    
Accrued expenses and other current liabilities $ 6,900   $ 6,900