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Consolidated Statements of Cash Flows - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Operating activities      
Net loss $ (236,568,000) $ (250,460,000) $ (276,852,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Amortization of debt discount and deferred financing 2,634,000 2,490,000 1,794,000
Depreciation and amortization 5,342,000 6,209,000 8,846,000
Share-based compensation 76,512,000 57,838,000 49,151,000
Loss on extinguishment of debt 0 257,000 7,276,000
Non-cash changes in the fair value of contingent consideration payable 1,078,000 6,514,000 3,144,000
Foreign currency remeasurement loss 6,121,000 3,565,000 5,471,000
Non-cash deferred taxes 9,000 34,000 (155,000)
Asset impairment charges and other asset write-offs 18,177,000 0 99,000
Changes in operating assets and liabilities:      
Accounts receivable (17,330,000) (8,189,000) (11,219,000)
Inventories (5,343,000) (7,790,000) (4,639,000)
Prepaid expenses and other current assets (6,194,000) (5,919,000) (8,766,000)
Accounts payable, accrued expenses, and other current liabilities (6,377,000) 7,430,000 (10,610,000)
Other non-current assets and liabilities (4,636,000) (4,117,000) 3,170,000
Payment of contingent consideration 0 (10,353,000) 0
Net cash used in operating activities (166,575,000) (202,491,000) (233,290,000)
Investing activities      
Sale and redemption of marketable securities 335,926,000 424,043,000 354,826,000
Purchases of marketable securities (243,255,000) (341,398,000) (365,178,000)
Capital expenditures (3,766,000) (3,884,000) (3,227,000)
Proceeds from sale of assets 3,411,000 0 0
Net cash provided by (used in) investing activities 92,316,000 78,761,000 (13,579,000)
Financing activities      
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs 0 199,750,000 0
Payment of long-term debt 0 0 (155,249,000)
Proceeds from long-term debt, net of issuance costs 0 0 385,929,000
Payment of finance leases (283,000) (479,000) (76,000)
Purchase of vested restricted stock units, net of taxes (11,490,000) (15,009,000) (10,028,000)
Proceeds from stock options exercised, net 4,310,000 10,228,000 42,282,000
Proceeds from warrants exercised, net 0 19,230,000 0
Payment of contingent consideration 0 (1,647,000) 0
Net cash (used in) provided by financing activities (7,463,000) 212,073,000 262,858,000
Effect of exchange rate changes on cash, cash equivalents, and restricted cash (14,619,000) (5,049,000) 3,830,000
Net increase in cash, cash equivalents, and restricted cash (96,341,000) 83,294,000 19,819,000
Cash, cash equivalents, and restricted cash at the beginning of the year 249,456,000 166,162,000 146,343,000
Cash, cash equivalents, and restricted cash at the end of the year 153,115,000 249,456,000 166,162,000
Supplemental disclosures of cash flow information      
Tenant improvements paid through lease incentive 0 300,000 470,000
Cash paid during the period for interest 34,358,000 30,468,000 24,683,000
Capital expenditures unpaid at the end of period 1,141,000 1,448,000 985,000
Cash paid for income taxes $ 1,609,000 $ 20,032,000 $ 10,371,000