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Income Taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2023 | Dec. 31, 2022
Operating Loss Carryforwards [Line Items] |  |
Valuation allowance | $ 649,254 | $ 632,233
Increase in the valuation allowance | 17,000 |
Federal |  |
Operating Loss Carryforwards [Line Items] |  |
Amount of net operating loss carry forwards | 1,200,000 |
Federal | Research and experimentation tax credit carryforward |  |
Operating Loss Carryforwards [Line Items] |  |
Tax credit carryforward amount | 18,400 |
Federal | Orphan drug tax credit carryforwards |  |
Operating Loss Carryforwards [Line Items] |  |
Tax credit carryforward amount | 203,100 |
Foreign |  |
Operating Loss Carryforwards [Line Items] |  |
Amount of net operating loss carry forwards | 28,400 |
State |  |
Operating Loss Carryforwards [Line Items] |  |
Amount of net operating loss carry forwards | 1,000,000 |
State | Research and experimentation tax credit carryforward |  |
Operating Loss Carryforwards [Line Items] |  |
Tax credit carryforward amount | $ 14,100 |

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