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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating activities |  |  |
Net loss | $ (151,584) | $ (236,568) | $ (250,460)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Amortization of debt discount and deferred financing | 2,616 | 2,634 | 2,490
Depreciation and amortization | 7,873 | 5,342 | 6,209
Stock-based compensation | 86,077 | 76,512 | 57,838
Loss on extinguishment of debt | 13,933 | 0 | 257
Non-cash changes in the fair value of contingent consideration payable | 2,583 | 1,078 | 6,514
Foreign currency remeasurement loss | 19,613 | 6,121 | 3,565
Non-cash deferred taxes | (4,939) | 9 | 34
Asset impairment charges and other asset write-offs | 2,727 | 18,177 | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (20,108) | (17,330) | (8,189)
Inventories | (44,614) | (5,343) | (7,790)
Prepaid expenses and other current assets | (8,062) | (6,194) | (5,919)
Accounts payable, accrued expenses, and other current liabilities | 49,195 | (6,377) | 7,430
Other non-current assets and liabilities | (3,054) | (4,636) | (4,117)
Payment of contingent consideration | (21,347) | 0 | (10,353)
Net cash used in operating activities | (69,091) | (166,575) | (202,491)
Investing activities |  |  |
Sale and redemption of marketable securities | 197,227 | 335,926 | 424,043
Purchases of marketable securities | (91,723) | (243,255) | (341,398)
Capital expenditures | (7,440) | (3,766) | (3,884)
Proceeds from sale of assets | 0 | 3,411 | 0
Net cash provided by investing activities | 98,064 | 92,316 | 78,761
Financing activities |  |  |
Proceeds from the issuance of shares in connection with at-the-market offering, net of issuance costs | 63,108 | 0 | 0
Proceeds from equity financing, net of issuance costs | 29,827 | 0 | 199,750
Withholding taxes paid on vested restricted stock units | (17,920) | (11,490) | (15,009)
Proceeds from stock options exercised, net | 10,261 | 4,310 | 10,228
Proceeds from warrants exercised, net | 12 | 0 | 19,230
Payment of long-term debt | (408,043) | 0 | 0
Proceeds from long-term debt, net of issuance costs | 387,360 | 0 | 0
Payment of contingent consideration | (2,653) | 0 | (1,647)
Payment of finance leases | (275) | (283) | (479)
Net cash provided by (used in) financing activities | 61,677 | (7,463) | 212,073
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | 6,312 | (14,619) | (5,049)
Net increase (decrease) in cash, cash equivalents, and restricted cash | 96,962 | (96,341) | 83,294
Cash, cash equivalents, and restricted cash at the beginning of the year | 153,115 | 249,456 | 166,162
Cash, cash equivalents, and restricted cash at the end of the year | 250,077 | 153,115 | 249,456
Supplemental disclosures of cash flow information |  |  |
Tenant improvements paid through lease incentive | 105 | 0 | 300
Cash paid during the period for interest | 36,090 | 34,358 | 30,468
Capital expenditures unpaid at the end of period | 868 | 1,141 | 1,448
Cash paid for income taxes | $ 8,525 | $ 1,609 | $ 20,032

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