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Income Taxes - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
Income Taxes - Narrative (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Operating Loss Carryforwards [Line Items]
Valuation allowance	$ 649,254	$ 632,233
Increase in the valuation allowance	17,000
Federal
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	1,200,000
Federal \| Research and experimentation tax credit carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	18,400
Federal \| Orphan drug tax credit carryforwards
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	203,100
Foreign
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	28,400
State
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	1,000,000
State \| Research and experimentation tax credit carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	$ 14,100