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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
At-The-Market
Private Placement
Common Stock
Common Stock
At-The-Market
Common Stock
Private Placement
Additional Paid-In Capital
Additional Paid-In Capital
At-The-Market
Additional Paid-In Capital
Private Placement
Warrants
Other Comprehensive Gain (Loss)
Accumulated Deficit
Balance (in shares) at Dec. 31, 2020       262,063,461                
Balance at Dec. 31, 2020 $ 286,380     $ 2,650     $ 2,308,578     $ 12,387 $ 8,227 $ (2,045,462)
Increase (Decrease) in Stockholders' Equity                        
Stock options exercised, net (in shares) 1,483,000     1,461,189                
Stock options exercised, net $ 10,228     $ 15     10,213          
Common stock issued from equity financing and pre-funded warrants, net of offering costs (in shares)       11,296,660                
Common stock issued from equity financing and pre-funded warrants, net of offering costs 199,747     $ 112     199,552     83    
Vesting of restricted stock units, net of taxes (in shares)       1,064,135                
Vesting of restricted stock units, net of taxes (15,009)           (15,009)          
Stock-based compensation 57,838           57,838          
Warrants exercised (in shares)       2,554,999                
Warrants exercised 19,230     $ 26     31,591     (12,387)    
Equity component of the convertible notes (in shares)       472,356                
Equity component of the convertible notes 2,661     $ 5     2,656          
Unrealized (loss) gain on available-for-sale securities (85)                   (85)  
Foreign currency translation adjustment (3,161)                   (3,161)  
Net loss (250,460)                     (250,460)
Balance (in shares) at Dec. 31, 2021       278,912,800                
Balance at Dec. 31, 2021 $ 307,369     $ 2,808     2,595,419     83 4,981 (2,295,922)
Increase (Decrease) in Stockholders' Equity                        
Stock options exercised, net (in shares) 660,000     656,377                
Stock options exercised, net $ 4,310     $ 7     4,303          
Vesting of restricted stock units, net of taxes (in shares)       1,539,096                
Vesting of restricted stock units, net of taxes (11,490)           (11,490)          
Stock-based compensation 76,512           76,512          
Unrealized (loss) gain on available-for-sale securities 154                   154  
Foreign currency translation adjustment (17,240)                   (17,240)  
Net loss $ (236,568)                     (236,568)
Balance (in shares) at Dec. 31, 2022 281,108,273     281,108,273                
Balance at Dec. 31, 2022 $ 123,047     $ 2,815     2,664,744     83 (12,105) (2,532,490)
Increase (Decrease) in Stockholders' Equity                        
Stock options exercised, net (in shares) 1,361,000     1,357,945                
Stock options exercised, net $ 10,261     $ 14     10,247          
Common stock issued from equity financing and pre-funded warrants, net of offering costs (in shares)         5,244,936 2,467,104            
Common stock issued from equity financing and pre-funded warrants, net of offering costs   $ 63,108 $ 29,827   $ 52 $ 25   $ 63,056 $ 29,802      
Vesting of restricted stock units, net of taxes (in shares)       2,195,851                
Vesting of restricted stock units, net of taxes (17,920)           (17,920)          
Stock-based compensation 86,077           86,077          
Warrants exercised (in shares)       1,220,100                
Warrants exercised 12     $ 12     12     (12)    
Unrealized (loss) gain on available-for-sale securities (72)                   (72)  
Foreign currency translation adjustment 17,418                   17,418  
Net loss $ (151,584)                     (151,584)
Balance (in shares) at Dec. 31, 2023 293,594,209     293,594,209                
Balance at Dec. 31, 2023 $ 160,174     $ 2,918     $ 2,836,018     $ 71 $ 5,241 $ (2,684,074)