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Collaborative Agreements (Details) $ in Thousands	1 Months Ended	12 Months Ended
	Nov. 30, 2013 USD ($) market	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Collaborative Agreements
Net product sales		$ 399,356	$ 329,233	$ 305,514
Accrued expenses and other current liabilities		144,245	93,636
Collaborative Arrangements
Collaborative Agreements
Conditional aggregate payments per indication		86,500	$ 23,700
Revised Agreement | GSK
Collaborative Agreements
Potential milestone payments upon achievement of post-approval and sales-based milestones	$ 40,000
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones | market	8
Deferred credits and other liabilities, noncurrent		5,900
Net product sales		27,700
Accrued expenses and other current liabilities		$ 8,200

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Collaborative Agreement, Conditional Aggregate Payments Per Indication

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Represents the amount of potential payments upon achievement of post-approval and sales-based milestones.

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Represents information pertaining to the number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones.

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Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits.

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Carrying amount as of the balance sheet date of unearned revenue or income, not otherwise specified in the taxonomy, which is expected to be taken into income after one year or beyond the normal operating cycle, if longer and noncurrent obligations not separately disclosed in the balance sheet (other liabilities, noncurrent).

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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