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Pay vs Performance Disclosure - USD ($)

5 Months Ended

7 Months Ended

12 Months Ended

Dec. 31, 2022

Jul. 31, 2022

Dec. 31, 2023

Dec. 31, 2022

Dec. 31, 2021

Dec. 31, 2020

Pay vs Performance Disclosure

Pay vs Performance Disclosure, Table

Pay Versus Performance

This disclosure has been prepared in accordance with the SEC’s pay versus performance rules in Item 402(v) of Regulation S-K under the 1934 Act (“Item 402(v)”) and does not necessarily reflect value actually realized by the Named Executive Officers or how the Compensation and Leadership Development Committee evaluates compensation decisions in light of Company or individual performance. For discussion of how the Compensation and Leadership Development Committee seeks to align pay with performance when making compensation decisions, please review the Compensation Discussion and Analysis beginning on page 25.

The following tables and related disclosures provide information about (i) the total compensation (“SCT Total”) of our principal executive officer (“PEO”) and our non-PEO named executive officers (collectively, the “Other NEOs”) as presented in the Summary Compensation Table on page 42, (ii) the “compensation actually paid” (“CAP”) to our PEO and our Other NEOs, as calculated pursuant to Item 402(v), (iii) certain financial performance measures, and (iv) the relationship of the CAP to those financial performance measures.

Year (a)	Summary Compen- sation Table Total for PEO: John F. Crowley ($) (b)	Summary Compen- sation Table Total for PEO: Bradley L. Campbell ($) (b)	Compen- sation Actually Paid to PEO: John F. Crowley ($) (c)	Compen- sation Actually Paid to PEO: Bradley L. Campbell ($) (c)	Average Summary Compen- sation Table Total for non-PEO Named Executive Officers ($) (d)	Average Compen- sation Actually Paid to non-PEO Named Executive Officers ($) (e)	Value of Initial Fixed $100 Investment on Dec. 31, 2019 Based on		Net Income ($) (thous- ands) (h)	Net Product Sales ($) (thous- ands) (i)
Year (a)							Total Share- holder Return (f)	Peer Group Total Share- holder Return (g)	Net Income ($) (thous- ands) (h)	Net Product Sales ($) (thous- ands) (i)
2023	$—	$8,202,366	$—	$10,611,184	$3,543,754	$4,339,706	$146	$118	$(151,584)	$399,356
2022	10,001,131	8,997,866	10,806,940	9,556,649	3,270,640	3,208,762	122	110	(236,568)	329,233
2021	9,990,032	—	(13,481,915)	—	3,307,641	(3,681,239)	119	125	(250,460)	305,514
2020	11,315,124	—	37,594,876	—	3,232,985	8,997,906	237	126	(276,852)	260,886

Names of PEO and Other NEOs (Column (b); Column (c); Column (d); Column (e))

2023: PEO: Bradley L. Campbell; Other NEOs: Simon Harford, Daphne Quimi, Ellen S. Rosenberg, David M. Clark, and Jeffrey P. Castelli.

2022: PEOs: John F. Crowley served as our PEO through August 1, 2022 and Bradley L. Campbell became our PEO effective August 1, 2022; Other NEOs: Daphne Quimi, Ellen S. Rosenberg, David M. Clark, and Jeffrey P. Castelli.

2021: PEO: John F. Crowley; Other NEOs: Bradley L. Campbell, Daphne Quimi, Ellen S. Rosenberg, David M. Clark, and Hung Do.

2020: PEO: John F. Crowley; Other NEOs: Bradley L. Campbell, Daphne Quimi, Ellen S. Rosenberg, Hung Do, and Jay Barth.

Adjustments to Calculate Compensation Actually Paid to PEO (Column (c)) and Average Compensation Actually Paid to Other NEOs (Column (e))

The table below describes the adjustments, each of which is required by SEC rules, to calculate CAP Amounts from the SCT Total of our PEO(s) (Columns (b) and (c)) and our Other NEOs (Column (d)). The SCT Total and CAP Amounts do not reflect the actual amount of compensation earned by or paid to our executives during the applicable years, but rather are amounts determined in accordance with Item 402(v).

	2023		2022			2021		2020
Adjustments	PEO	Other NEOs*	PEO: John F. Crowley	PEO: Bradley L. Campbell	Other NEOs*	PEO	Other NEOs*	PEO	Other NEOs*
SCT Totals	$8,202,366	$3,543,754	$10,001,131	$8,997,866	$3,270,640	$9,990,032	$3,307,641	$11,315,124	$3,232,985
Adjustments for stock awards and option awards
(Deduct): Aggregate value for stock awards and option awards included in SCT Total for the covered fiscal year	(6,758,183)	(2,780,664)	(8,122,327)	(8,013,779)	(2,540,515)	(7,927,324)	(2,536,712)	(7,972,462)	(2,444,876)

	2023		2022			2021		2020
Adjustments	PEO	Other NEOs*	PEO: John F. Crowley	PEO: Bradley L. Campbell	Other NEOs*	PEO	Other NEOs*	PEO	Other NEOs*
Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end	8,000,556	3,272,070	9,660,582	8,908,774	2,670,154	3,494,888	1,127,092	20,957,289	5,365,039
Add (Deduct): Year-over-year change in fair value at covered fiscal year end of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end	1,365,682	365,337	391,911	188,427	107,386	(11,768,843)	(3,516,814)	11,187,359	2,592,973
Add: Vesting date fair value of awards granted and vested during the covered fiscal year	—	—	—	—	—	—	—	—	12,278
(Deduct) Add: Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year	(58,529)	(994)	357,923	167,091	86,488	(5,922,905)	(1,712,039)	2,367,147	502,296
(Deduct): Fair value at end of prior fiscal year of awards granted in any prior fiscal year that failed to meet the applicable vesting conditions during the covered fiscal year	(140,708)	(59,797)	(1,482,280)	(691,730)	(385,391)	(1,347,763)	(350,407)	(259,581)	(262,789)
CAP Amounts (as calculated)	$10,611,184	$4,339,706	$10,806,940	$9,556,649	$3,208,762	$(13,481,915)	$(3,681,239)	$37,594,876	$8,997,906

*	Amounts presented are averages for the entire group of Other NEOs in each respective year

Total Shareholder Return (Column (f); Column (g))

The share prices illustrate the cumulative total shareholder return (“TSR”) each year of Amicus common stock and of the Nasdaq Biotechnology Index (the “Peer Group”) since December 31, 2019, of a $100 investment. All values assume reinvestment of the full amount of all dividends, however no dividends have been declared on our common stock to date. The Peer Group used in this disclosure is the same Peer Group used in Part II, Item 5 of our Form 10-K.

Net Income (Column (h))

Reported in the Company’s Consolidated Statements of Operations included in our Form 10-K as “Net Loss,” which is how we’ve referred to this performance measure in the graphs that follow.

Net Product Sales (Column (i))

Net product sales as reported in the Company’s Consolidated Statements of Operations included in our Form 10-K. Net product sales was determined to be the most important financial performance measure linking CAP to Company performance for 2023 and therefore was selected as the 2023 “Company-Selected Measure” as defined in Item 402(v).

Company Selected Measure Name

Net product sales

Named Executive Officers, Footnote

Names of PEO and Other NEOs (Column (b); Column (c); Column (d); Column (e))

2023: PEO: Bradley L. Campbell; Other NEOs: Simon Harford, Daphne Quimi, Ellen S. Rosenberg, David M. Clark, and Jeffrey P. Castelli.

2021: PEO: John F. Crowley; Other NEOs: Bradley L. Campbell, Daphne Quimi, Ellen S. Rosenberg, David M. Clark, and Hung Do.

2020: PEO: John F. Crowley; Other NEOs: Bradley L. Campbell, Daphne Quimi, Ellen S. Rosenberg, Hung Do, and Jay Barth.

Peer Group Issuers, Footnote

Total Shareholder Return (Column (f); Column (g))

Adjustment To PEO Compensation, Footnote

Adjustments to Calculate Compensation Actually Paid to PEO (Column (c)) and Average Compensation Actually Paid to Other NEOs (Column (e))

	2023		2022			2021		2020
Adjustments	PEO	Other NEOs*	PEO: John F. Crowley	PEO: Bradley L. Campbell	Other NEOs*	PEO	Other NEOs*	PEO	Other NEOs*
SCT Totals	$8,202,366	$3,543,754	$10,001,131	$8,997,866	$3,270,640	$9,990,032	$3,307,641	$11,315,124	$3,232,985
Adjustments for stock awards and option awards
(Deduct): Aggregate value for stock awards and option awards included in SCT Total for the covered fiscal year	(6,758,183)	(2,780,664)	(8,122,327)	(8,013,779)	(2,540,515)	(7,927,324)	(2,536,712)	(7,972,462)	(2,444,876)

	2023		2022			2021		2020
Adjustments	PEO	Other NEOs*	PEO: John F. Crowley	PEO: Bradley L. Campbell	Other NEOs*	PEO	Other NEOs*	PEO	Other NEOs*
Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end	8,000,556	3,272,070	9,660,582	8,908,774	2,670,154	3,494,888	1,127,092	20,957,289	5,365,039
Add (Deduct): Year-over-year change in fair value at covered fiscal year end of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end	1,365,682	365,337	391,911	188,427	107,386	(11,768,843)	(3,516,814)	11,187,359	2,592,973
Add: Vesting date fair value of awards granted and vested during the covered fiscal year	—	—	—	—	—	—	—	—	12,278
(Deduct) Add: Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year	(58,529)	(994)	357,923	167,091	86,488	(5,922,905)	(1,712,039)	2,367,147	502,296
(Deduct): Fair value at end of prior fiscal year of awards granted in any prior fiscal year that failed to meet the applicable vesting conditions during the covered fiscal year	(140,708)	(59,797)	(1,482,280)	(691,730)	(385,391)	(1,347,763)	(350,407)	(259,581)	(262,789)
CAP Amounts (as calculated)	$10,611,184	$4,339,706	$10,806,940	$9,556,649	$3,208,762	$(13,481,915)	$(3,681,239)	$37,594,876	$8,997,906

*	Amounts presented are averages for the entire group of Other NEOs in each respective year

Non-PEO NEO Average Total Compensation Amount

$ 3,543,754

$ 3,270,640

$ 3,307,641

$ 3,232,985

Non-PEO NEO Average Compensation Actually Paid Amount

$ 4,339,706

3,208,762

(3,681,239)

8,997,906

Adjustment to Non-PEO NEO Compensation Footnote

Adjustments to Calculate Compensation Actually Paid to PEO (Column (c)) and Average Compensation Actually Paid to Other NEOs (Column (e))

	2023		2022			2021		2020
Adjustments	PEO	Other NEOs*	PEO: John F. Crowley	PEO: Bradley L. Campbell	Other NEOs*	PEO	Other NEOs*	PEO	Other NEOs*
SCT Totals	$8,202,366	$3,543,754	$10,001,131	$8,997,866	$3,270,640	$9,990,032	$3,307,641	$11,315,124	$3,232,985
Adjustments for stock awards and option awards
(Deduct): Aggregate value for stock awards and option awards included in SCT Total for the covered fiscal year	(6,758,183)	(2,780,664)	(8,122,327)	(8,013,779)	(2,540,515)	(7,927,324)	(2,536,712)	(7,972,462)	(2,444,876)

	2023		2022			2021		2020
Adjustments	PEO	Other NEOs*	PEO: John F. Crowley	PEO: Bradley L. Campbell	Other NEOs*	PEO	Other NEOs*	PEO	Other NEOs*
Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end	8,000,556	3,272,070	9,660,582	8,908,774	2,670,154	3,494,888	1,127,092	20,957,289	5,365,039
Add (Deduct): Year-over-year change in fair value at covered fiscal year end of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end	1,365,682	365,337	391,911	188,427	107,386	(11,768,843)	(3,516,814)	11,187,359	2,592,973
Add: Vesting date fair value of awards granted and vested during the covered fiscal year	—	—	—	—	—	—	—	—	12,278
(Deduct) Add: Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year	(58,529)	(994)	357,923	167,091	86,488	(5,922,905)	(1,712,039)	2,367,147	502,296
(Deduct): Fair value at end of prior fiscal year of awards granted in any prior fiscal year that failed to meet the applicable vesting conditions during the covered fiscal year	(140,708)	(59,797)	(1,482,280)	(691,730)	(385,391)	(1,347,763)	(350,407)	(259,581)	(262,789)
CAP Amounts (as calculated)	$10,611,184	$4,339,706	$10,806,940	$9,556,649	$3,208,762	$(13,481,915)	$(3,681,239)	$37,594,876	$8,997,906

*	Amounts presented are averages for the entire group of Other NEOs in each respective year

Compensation Actually Paid vs. Total Shareholder Return

Relationship Between Compensation Actually Paid and Performance

The graphs below show the relationship of “compensation actually paid” to our PEO and Other NEOs to (i) the Company’s net product sales growth and net loss and (ii) TSR of both the Company and the Nasdaq Biotechnology Index.

CAP, as calculated in accordance with Item 402(v), reflects, among others, adjustments to the fair value of equity awards during the years presented. In light of the significant weighting of long-term stock-based incentives in our pay mix (which approximates a range of 79%-89% for our PEOs and 74%-79% for our Other NEOs, of total compensation) due to the intended alignment between our executives and stockholders, CAP values are significantly influenced by the value of our stock price as well as the projected and actual achievement of performance goals. CAP in 2021 reflects a significant decrease in the value of prior year awards and awards granted in 2021 compared to their grant date. Conversely, CAP in both 2022 and 2023 reflects increases in the value of prior year awards as well as current year awards compared to their grant date, offset by prior year performance-based awards that failed to meet applicable vesting conditions.

Compensation Actually Paid vs. Net Income

Relationship Between Compensation Actually Paid and Performance

Compensation Actually Paid vs. Company Selected Measure

Relationship Between Compensation Actually Paid and Performance

Total Shareholder Return Vs Peer Group

Relationship Between Compensation Actually Paid and Performance

Tabular List, Table

Financial Performance Measures

The following table lists the financial performance measures that, in the Company’s assessment, represent the most important performance measures used to link CAP for our Named Executive Officers to Company performance for 2023.