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Collaborative Agreements (Details) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2013 USD ($) market | Dec. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($)
Collaborative Agreements |  |  |  |
Net product sales |  | $ 528,295 | $ 399,356 | $ 329,233
Accrued expenses and other current liabilities |  | 127,300 | $ 144,245 |
Revised Agreement | GSK |  |  |  |
Collaborative Agreements |  |  |  |
Potential milestone payments upon achievement of post-approval and sales-based milestones | $ 40,000 |  |  |
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones | market | 8 |  |  |
Deferred credits and other liabilities, noncurrent |  | 4,700 |  |
Net product sales |  | 32,700 |  |
Accrued expenses and other current liabilities |  | $ 9,800 |  |

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