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Income Taxes - Narrative (Details) - USD ($) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023
Operating Loss Carryforwards [Line Items] |  |
Unrecognized tax benefits that would impact effective tax rate | $ 13,800,000 | $ 4,800,000
Accrued interest | 1,900,000 |
Accrual for penalties | 0 |
Valuation allowance | 609,130,000 | $ 649,254,000
Decrease in the valuation allowance | 40,200,000 |
Federal |  |
Operating Loss Carryforwards [Line Items] |  |
Amount of net operating loss carry forwards | 1,100,000,000 |
Federal | Research and experimentation tax credit carryforward |  |
Operating Loss Carryforwards [Line Items] |  |
Tax credit carryforward amount | 19,100,000 |
Federal | Orphan drug tax credit carryforwards |  |
Operating Loss Carryforwards [Line Items] |  |
Tax credit carryforward amount | 201,600,000 |
State |  |
Operating Loss Carryforwards [Line Items] |  |
Amount of net operating loss carry forwards | 1,000,000,000.0 |
State | Research and experimentation tax credit carryforward |  |
Operating Loss Carryforwards [Line Items] |  |
Tax credit carryforward amount | $ 13,500,000 |

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