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Summary of Significant Accounting Policies - Revenue by Product and Geographical Area (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Disaggregation of Revenue [Line Items]      
Net product sales $ 528,295 $ 399,356 $ 329,233
Galafold      
Disaggregation of Revenue [Line Items]      
Net product sales 458,054 387,777 329,046
Pombiliti + Opfolda      
Disaggregation of Revenue [Line Items]      
Net product sales 70,241 11,579 187
UNITED STATES | Galafold      
Disaggregation of Revenue [Line Items]      
Net product sales 176,024 145,147 115,759
UNITED STATES | Pombiliti + Opfolda      
Disaggregation of Revenue [Line Items]      
Net product sales 30,123 1,791 0
Non-US | Galafold      
Disaggregation of Revenue [Line Items]      
Net product sales 282,030 242,630 213,287
Non-US | Pombiliti + Opfolda      
Disaggregation of Revenue [Line Items]      
Net product sales $ 40,118 $ 9,788 $ 187