Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
Dec. 31, 2024	Dec. 31, 2023
Operating Loss Carryforwards [Line Items]
Unrecognized tax benefits that would impact effective tax rate	$ 13,800,000	$ 4,800,000
Accrued interest	1,900,000
Accrual for penalties	0
Valuation allowance	609,130,000	$ 649,254,000
Decrease in the valuation allowance	40,200,000
Federal
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	1,100,000,000
Federal \| Research and experimentation tax credit carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	19,100,000
Federal \| Orphan drug tax credit carryforwards
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	201,600,000
State
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	1,000,000,000.0
State \| Research and experimentation tax credit carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	$ 13,500,000

Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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-Topic 740
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Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Amount of statutory penalties accrued for a tax position claimed or expected to be claimed by the entity, in its tax return.

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-Topic 740
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The total amount of unrecognized tax benefits that, if recognized, would affect the effective tax rate.

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Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset.

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