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Income Taxes - Deferred and Valuation Allowance (Details) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets
Net operating loss carry forwards	$ 302,066	$ 321,004
Research tax credit	234,189	235,532
Capitalized research and development costs	34,883	34,425
Share-based compensation	20,045	17,314
Lease liability	10,026	10,567
Interest carry forward limitation	9,097	17,627
Inventory	1,599	1,931
Other	5,267	20,858
Gross deferred tax assets	617,172	659,258
Deferred tax liabilities
Other	(8,042)	(10,004)
Total net deferred tax assets	609,130	649,254
Less: valuation allowance	(609,130)	(649,254)
Net deferred tax liability	$ 0	$ 0

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