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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Operating activities:    
Net loss $ (27,519) $ (24,515)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,623 1,162
Stock-based compensation expense 9,073 10,018
Deferred income tax benefit (124) (93)
Non-cash interest items, net 149 253
Loss on disposal of assets 36 0
Amortization of net premiums on marketable debt securities 201 572
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (847) (13)
Other assets 0 126
Accounts payable 117 725
Accrued expenses and other liabilities 1,878 434
Due to related parties 20 1,314
Deferred rent and revenue (118) (40)
Net cash used in operating activities (15,511) (10,057)
Investing activities:    
Purchases of property, plant and equipment (4,902) (4,509)
Purchase of equity investment 0 (8,500)
Purchases of marketable debt securities (32,038) (25,207)
Sales/maturities of marketable debt securities 39,860 54,254
Net cash provided by investing activities 2,920 16,038
Financing activities:    
Principal payments of financing obligations (65) (22)
Proceeds from exercise of stock options and warrants 23 1,154
Repurchase of common stock with commissions 0 (1,050)
Net share settlement for RSU vesting and option exercises (43) (550)
Net cash used in financing activities (85) (468)
Net increase (decrease) in cash, cash equivalents and restricted cash (12,676) 5,513
Cash, cash equivalents and restricted cash, beginning of period 24,051 8,262
Cash, cash equivalents and restricted cash, end of period 11,375 13,775
Reconciliation of cash, cash equivalents and restricted cash at end of period:    
Cash and cash equivalents 11,196 13,596
Restricted cash included in other assets 179 179
Cash, cash equivalents and restricted cash, end of period 11,375 13,775
Supplemental disclosure of cash flow information:    
Interest 34 37
Income taxes 0 0
Supplemental disclosure of non-cash investing and financing activities:    
Property and equipment purchases included in accounts payable and accrued expenses 5,930 2,492
Unrealized gain (loss) on marketable debt securities $ (174) $ 70