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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Operating activities:      
Net loss $ (583,852) $ (417,320) $ (349,848)
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock-based compensation expense 49,163 40,179 57,181
Change in fair value of warrant liabilities 47,600 (13,460) 0
Amortization of related-party notes discounts 42,396 16,282 62
Change in fair value of convertible note 36,203 0 0
Depreciation and amortization 18,512 18,260 14,238
Non-cash interest items, net (including amounts with related parties) 9,189 11,746 12,417
Non-cash lease expense related to operating lease right-of-use assets 6,112 5,932 4,884
Transaction costs allocated to warrant liabilities 2,010 1,082 0
Unrealized losses on equity securities 1,591 4,190 4,615
Impairment of intangible assets 886 681 0
Amortization of premiums, net of discounts, on marketable debt securities (137) 1,318 403
Impairment of fixed assets 0 1,333 0
Other (407) 269 741
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets 5,958 (16,557) (2,249)
Other assets 1,913 1,998 (3,977)
Accounts payable (6,476) 8,000 (3,717)
Accrued expenses and other liabilities 6,689 4,102 5,182
Related parties (1,129) (1,225) (10,187)
Operating lease liabilities (2,978) (4,319) (4,164)
Net cash used in operating activities (366,757) (337,509) (274,419)
Investing activities:      
Purchases of property, plant and equipment (30,584) (78,162) (33,563)
Purchase of intangible assets 0 (21,229) 0
Proceeds from sales of property, plant and equipment 0 0 20,498
Purchases of marketable debt securities, available-for-sale (10,358) (34,312) (141,750)
Maturities of marketable debt securities, available for sale 10,100 128,188 56,166
Proceeds from sales of marketable debt and equity securities 372 33,812 13,763
Investment in joint venture – an equity method investment 0 (1,000) 0
Net cash (used in) provided by investing activities (30,470) 27,297 (84,886)
Financing activities:      
Proceeds from issuance of related-party promissory notes net of issuance costs paid 258,700 174,125 338,500
Proceeds from the RIPA, net of transaction costs 192,764 0 0
Proceeds from exercises of stock options 294 74 5,461
Net share settlement for RSUs vesting (3,443) (616) (4,064)
Principal payments of finance leases (77) (58) 0
Sale of assets to an entity under common control 0 0 1,435
Payment for contingent consideration 0 (339) (419)
Net cash provided by financing activities 558,341 233,613 505,443
Effect of exchange rate changes on cash, cash equivalents, and restricted cash (292) 284 48
Net change in cash, cash equivalents, and restricted cash 160,822 (76,315) 146,186
Cash, cash equivalents, and restricted cash, beginning of year 104,965 181,280 35,094
Cash, cash equivalents, and restricted cash, end of year 265,787 104,965 181,280
Reconciliation of cash, cash equivalents, and restricted cash, end of year:      
Cash and cash equivalents 265,453 104,641 181,101
Restricted cash (Note 2) 334 324 179
Cash, cash equivalents, and restricted cash, end of year 265,787 104,965 181,280
Supplemental disclosure of cash flow information:      
Interest 77,192 35,442 2,106
Income taxes 8 2 9
Supplemental disclosure of non-cash activities:      
Conversion of related-party convertible notes and accrued interest, net of unamortized discount, into equity 269,987 51,947 0
Initial measurement of warrants issued in connection with registered direct offerings accounted for as liabilities 49,534 35,096 0
Gain on extinguishment of debt with related parties under common control 36,110 82,858 0
Increase in fair value of embedded conversion feature from debt modification 31,179 0 0
Common stock issuance discount related to the revenue interest liability 2,039 0 0
Property and equipment purchases included in accounts payable, accrued expenses and due to related parties 1,156 12,693 11,654
Right-of-use assets obtained in exchange for operating lease liabilities 0 14,798 23,069
Right-of-use assets disposed in exchange for operating lease liabilities (3,777) 0 0
Common stock issued pursuant to litigation settlement 0 10,656 0
Unpaid offering and transaction costs included in accounts payable and accrued expenses 255 277 0
Cashless exercise of stock options 0 0 1,035
Accrued investment in joint venture 0 0 1,000
Private Placement and At The Market Offerings      
Financing activities:      
Issuance of common stock 100,561 60,427 164,530
Stock Purchase and Option Agreement      
Financing activities:      
Issuance of common stock $ 9,542 $ 0 $ 0