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Stock Option and Grant Plan (Tables)

9 Months Ended

Sep. 30, 2022

Share-Based Payment Arrangement [Abstract]

Summary of Stock-based Compensation Expense

Stock-based compensation expense recorded as research and development and general and administrative expenses in the condensed consolidated statements of operations and other comprehensive loss is as follows (in thousands):

		Three Months Ended September 30,								Nine Months Ended September 30,
		2022				2021				2022				2021
Research and development		$	13,859			$	7,554				38,581				17,049
General and administrative			8,350				5,414				23,241				11,019
Total stock-based compensation expense		$	22,209			$	12,968			$	61,822			$	28,068

Summary of Option Activity Under Equity Award Plans

The following table provides a summary of option activity under the Company’s equity award plans:

		Number of options				Weighted average exercise price
Outstanding at December 31, 2021			6,034,192			$	32.40
Granted			2,051,846				62.32
Exercised			(369,444	)			5.33
Forfeitures			(109,531	)			55.89
Outstanding at September 30, 2022			7,607,063				41.45
Exercisable as of September 30, 2022			3,421,139				24.52

Summary of Restricted Stock Activity

The following table summarizes the Company’s restricted stock activity:

		Shares				Weighted- average grant date fair value
Unvested as of December 31, 2021			1,126,206			$	74.32
Issued			937,725				53.52
Vested			(379,287	)			51.00
Forfeited			(36,865	)			75.65
Unvested as of September 30, 2022			1,647,779			$	67.82

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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