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Nature of the Business and Basis of Presentation - Additional Information (Details) - USD ($)
1 Months Ended 4 Months Ended 9 Months Ended 15 Months Ended
Apr. 30, 2021
Jul. 31, 2021
Sep. 30, 2022
Sep. 30, 2022
Dec. 31, 2021
Jul. 07, 2021
Nature Of Business And Basis Of Presentation [Line Items]            
Accumulated deficit     $ 1,019,013,000 $ 1,019,013,000 $ 768,274,000  
Cash, cash equivalents, and marketable securities     1,100,000,000 1,100,000,000    
Jeffries LLC Amended Sales Agreement            
Nature Of Business And Basis Of Presentation [Line Items]            
Gross proceeds from issuance of common stock     $ 289,300,000 $ 289,300,000    
Jeffries LLC Amended Sales Agreement | Common Stock            
Nature Of Business And Basis Of Presentation [Line Items]            
Stock sold during period shares, new issues       3,248,633    
Price per share of stock sold     $ 89.06 $ 89.06    
Jeffries LLC Amended Sales Agreement | At-The-Market            
Nature Of Business And Basis Of Presentation [Line Items]            
Aggregate gross proceeds of shares authorized under ATM sales agreement           $ 500,000,000.0
Jeffries LLC Sales Agreement            
Nature Of Business And Basis Of Presentation [Line Items]            
Gross proceeds from issuance of common stock   $ 300,000,000.0        
Jeffries LLC Sales Agreement | Common Stock            
Nature Of Business And Basis Of Presentation [Line Items]            
Stock sold during period shares, new issues   2,908,009        
Price per share of stock sold   $ 103.16        
Jeffries LLC Sales Agreement | Maximum | At-The-Market            
Nature Of Business And Basis Of Presentation [Line Items]            
Commission rate 3.00%          
Aggregate gross proceeds of shares authorized under ATM sales agreement $ 300,000,000.0