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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning Balance at Dec. 31, 2020 $ 245,561 $ 573 $ 642,633 $ (9) $ (397,636)
Beginning Balance, Shares at Dec. 31, 2020   57,254,178      
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs 252,005 $ 28 251,977    
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs, Shares   2,795,700      
Issuance of common stock to acquire Guide 120,032 $ 10 120,022    
Issuance of common stock to acquire Guide, Shares   1,087,153      
Vesting of restricted common stock   $ 4 (4)    
Vesting of restricted common stock, Shares   398,804      
Stock-based compensation 4,648   4,648    
Exercise of common stock options 1,758 $ 2 1,756    
Exercise of common stock options, Shares   199,284      
Other comprehensive income (loss) (15)     (15)  
Net loss (201,560)       (201,560)
Ending Balance at Mar. 31, 2021 422,429 $ 617 1,021,032 (24) (599,196)
Ending Balance, Shares at Mar. 31, 2021   61,735,119      
Beginning Balance at Dec. 31, 2020 245,561 $ 573 642,633 (9) (397,636)
Beginning Balance, Shares at Dec. 31, 2020   57,254,178      
Net loss (305,931)        
Ending Balance at Sep. 30, 2021 853,814 $ 677 1,556,685 19 (703,567)
Ending Balance, Shares at Sep. 30, 2021   67,734,484      
Beginning Balance at Mar. 31, 2021 422,429 $ 617 1,021,032 (24) (599,196)
Beginning Balance, Shares at Mar. 31, 2021   61,735,119      
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs 157,785 $ 18 157,767    
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs, Shares   1,761,285      
Vesting of restricted common stock   $ 2 (2)    
Vesting of restricted common stock, Shares   200,403      
Issuance of common stock for success payment liability 30,000 $ 4 29,996    
Issuance of common stock for success payment liability, Shares   349,650      
Stock-based compensation 10,452   10,452    
Exercise of common stock options 4,083 $ 4 4,079    
Exercise of common stock options, Shares   406,225      
Other comprehensive income (loss) 55     55  
Net loss (76,253)       (76,253)
Ending Balance at Jun. 30, 2021 548,551 $ 645 1,223,324 31 (675,449)
Ending Balance, Shares at Jun. 30, 2021   64,452,682      
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs 318,609 $ 29 318,580    
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs, Shares   2,912,557      
Vesting of restricted common stock   $ 2 (2)    
Vesting of restricted common stock, Shares   200,402      
Stock-based compensation 12,968   12,968    
Exercise of common stock options 1,816 $ 1 1,815    
Exercise of common stock options, Shares   168,843      
Other comprehensive income (loss) (12)     (12)  
Net loss (28,118)       (28,118)
Ending Balance at Sep. 30, 2021 853,814 $ 677 1,556,685 19 (703,567)
Ending Balance, Shares at Sep. 30, 2021   67,734,484      
Beginning Balance at Dec. 31, 2021 826,738 $ 684 1,594,378 (50) (768,274)
Beginning Balance, Shares at Dec. 31, 2021   68,389,425      
Purchase of common stock under ESPP 1,412   1,412    
Purchase of common stock under ESPP, Shares   28,990      
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs 53,936 $ 9 53,927    
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs, Shares   874,770      
Vesting of restricted common stock   $ 3 (3)    
Vesting of restricted common stock, Shares   283,186      
Stock-based compensation 18,035   18,035    
Exercise of common stock options 820 $ 2 818    
Exercise of common stock options, Shares   176,652      
Other comprehensive income (loss) (2,659)     (2,659)  
Net loss (69,214)       (69,214)
Ending Balance at Mar. 31, 2022 829,068 $ 698 1,668,567 (2,709) (837,488)
Ending Balance, Shares at Mar. 31, 2022   69,753,023      
Beginning Balance at Dec. 31, 2021 $ 826,738 $ 684 1,594,378 (50) (768,274)
Beginning Balance, Shares at Dec. 31, 2021   68,389,425      
Exercise of common stock options, Shares 369,444        
Net loss $ (250,739)        
Ending Balance at Sep. 30, 2022 714,477 $ 705 1,737,459 (4,674) (1,019,013)
Ending Balance, Shares at Sep. 30, 2022   70,457,676      
Beginning Balance at Mar. 31, 2022 829,068 $ 698 1,668,567 (2,709) (837,488)
Beginning Balance, Shares at Mar. 31, 2022   69,753,023      
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs 22,300 $ 4 22,296    
Issuance of common stock from private placement/At-the-Market offering, net of issuance costs, Shares   374,677      
Vesting of restricted common stock, Shares   37,118      
Stock-based compensation 21,578   21,578    
Exercise of common stock options 646 $ 1 645    
Exercise of common stock options, Shares   147,296      
Other comprehensive income (loss) (1,481)     (1,481)  
Net loss (71,950)       (71,950)
Ending Balance at Jun. 30, 2022 800,161 $ 703 1,713,086 (4,190) (909,438)
Ending Balance, Shares at Jun. 30, 2022   70,312,114      
Purchase of common stock under ESPP 1,664   1,664    
Purchase of common stock under ESPP, Shares   41,083      
Vesting of restricted common stock   $ 1 (1)    
Vesting of restricted common stock, Shares   58,983      
Stock-based compensation 22,209   22,209    
Exercise of common stock options 502 $ 1 501    
Exercise of common stock options, Shares   45,496      
Other comprehensive income (loss) (484)     (484)  
Net loss (109,575)       (109,575)
Ending Balance at Sep. 30, 2022 $ 714,477 $ 705 $ 1,737,459 $ (4,674) $ (1,019,013)
Ending Balance, Shares at Sep. 30, 2022   70,457,676