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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | ATM Offering | ATM Offering Common Stock | ATM Offering Additional Paid-in Capital
--- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2021 | $ 826,738 | $ 684 | $ 1,594,378 | $ (50) | $ (768,274) |  |  |
Beginning Balance, Shares at Dec. 31, 2021 |  | 68,389,425 |  |  |  |  |  |
Purchase of common stock under ESPP | 3,075 |  | 3,075 |  |  |  |  |
Purchase of common stock under ESPP, Shares |  | 70,073 |  |  |  |  |  |
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs |  |  |  |  |  | $ 108,076 | $ 19 | $ 108,057
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares |  |  |  |  |  |  | 1,909,103 |
Vesting of restricted common stock |  | $ 4 | (4) |  |  |  |  |
Vesting of restricted common stock, Shares |  | 424,303 |  |  |  |  |  |
Stock-based compensation | 84,321 |  | 84,321 |  |  |  |  |
Exercise of common stock options | 2,732 | $ 5 | 2,727 |  |  |  |  |
Exercise of common stock options, Shares |  | 484,435 |  |  |  |  |  |
Other comprehensive income (loss) | (2,380) |  |  | (2,380) |  |  |  |
Net loss | (289,088) |  |  |  | (289,088) |  |  |
Ending Balance at Dec. 31, 2022 | 733,474 | $ 712 | 1,792,554 | (2,430) | (1,057,362) |  |  |
Ending Balance, Shares at Dec. 31, 2022 |  | 71,277,339 |  |  |  |  |  |
Purchase of common stock under ESPP | 3,032 | $ 1 | 3,031 |  |  |  |  |
Purchase of common stock under ESPP, Shares |  | 130,403 |  |  |  |  |  |
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs |  |  |  |  |  | $ 235,938 | $ 70 | $ 235,868
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares |  |  |  |  |  |  | 6,952,703 |
Issuance of unregistered common shares in connection with license agreement | 33,600 | $ 20 | 33,580 |  |  |  |  |
Issuance of unregistered common shares in connection with license agreement, shares |  | 2,004,811 |  |  |  |  |  |
Vesting of restricted common stock |  | $ 5 | (5) |  |  |  |  |
Vesting of restricted common stock, Shares |  | 469,531 |  |  |  |  |  |
Stock-based compensation | 98,647 |  | 98,647 |  |  |  |  |
Exercise of common stock options | 6,131 | $ 8 | 6,123 |  |  |  |  |
Exercise of common stock options, Shares |  | 797,709 |  |  |  |  |  |
Other comprehensive income (loss) | 3,034 |  |  | 3,034 |  |  |  |
Net loss | (132,527) |  |  |  | (132,527) |  |  |
Ending Balance at Dec. 31, 2023 | 981,329 | $ 816 | 2,169,798 | 604 | (1,189,889) |  |  |
Ending Balance, Shares at Dec. 31, 2023 |  | 81,632,496 |  |  |  |  |  |
Purchase of common stock under ESPP | 2,621 | $ 1 | 2,620 |  |  |  |  |
Purchase of common stock under ESPP, Shares |  | 135,187 |  |  |  |  |  |
Vesting of restricted common stock |  | $ 13 | (13) |  |  |  |  |
Vesting of restricted common stock, Shares |  | 1,302,037 |  |  |  |  |  |
Stock-based compensation | 120,662 |  | 120,662 |  |  |  |  |
Exercise of common stock options | $ 5,600 | $ 6 | 5,594 |  |  |  |  |
Exercise of common stock options, Shares | 563,349 | 563,349 |  |  |  |  |  |
Other comprehensive income (loss) | $ 75 |  |  | 75 |  |  |  |
Net loss | (376,742) |  |  |  | (376,742) |  |  |
Ending Balance at Dec. 31, 2024 | $ 733,545 | $ 836 | $ 2,298,661 | $ 679 | $ (1,566,631) |  |  |
Ending Balance, Shares at Dec. 31, 2024 |  | 83,633,069 |  |  |  |  |  |

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