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Nature of the Business and Basis of Presentation - Additional Information (Details) - USD ($) | 1 Months Ended | 12 Months Ended | 45 Months Ended |
--- | --- | --- | --- | ---
Nov. 30, 2023 | Oct. 31, 2023 | Dec. 31, 2024 | Dec. 31, 2024 | Dec. 31, 2023
Nature Of Business And Basis Of Presentation [Line Items] |  |  |  |  |
Accumulated deficit |  |  | $ 1,566,631,000 | $ 1,566,631,000 | $ 1,189,889,000
Cash, cash equivalents, and marketable securities |  |  | $ 850,700,000 | $ 850,700,000 |
Jeffries LLC Sales Agreement |  |  |  |  |
Nature Of Business And Basis Of Presentation [Line Items] |  |  |  |  |
Stock sold during period shares, new issues |  |  | 0 | 13,769,001 |
Gross proceeds from issuance of common stock |  |  |  | $ 864,000,000 |
Jeffries LLC Sales Agreement | Common Stock |  |  |  |  |
Nature Of Business And Basis Of Presentation [Line Items] |  |  |  |  |
Price per share of shares issued |  |  | $ 62.75 | $ 62.75 |
Jeffries LLC Sales Agreement | Maximum | ATM Offering |  |  |  |  |
Nature Of Business And Basis Of Presentation [Line Items] |  |  |  |  |
Commission rate |  |  |  | 3.00% |
Aggregate gross proceeds of shares authorized under ATM sales agreement |  |  | $ 1,100,000,000 | $ 1,100,000,000 |
Lilly Agreement |  |  |  |  |
Nature Of Business And Basis Of Presentation [Line Items] |  |  |  |  |
Stock purchase agreement amount received |  | $ 50,000,000 |  |  |
Collaboration agreement upfront payment received | $ 200,000,000 |  |  |  |
Sale and issuance of common stock |  | 2,004,811 |  |  |
Aggregated purchase price |  | $ 50,000,000 |  |  |
Lilly Agreement | Maximum |  |  |  |  |
Nature Of Business And Basis Of Presentation [Line Items] |  |  |  |  |
Additional proceeds from potential future development-stage payments |  | $ 350,000,000 |  |  |

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