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Fair Value of Financial Instruments - Additional Information (Details) - USD ($) $ in Thousands |  | 12 Months Ended |
--- | --- | --- | ---
Jul. 19, 2024 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Feb. 23, 2021
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Equity securities recognition amount |  | $ (14,093) | $ (18,592) | $ 20,200 |
Settlement agreement upfront payment | $ 15,000 |  |  |  |
Percentage of royalty payment | 1.00% |  |  |  |
Settlement agreement upfront payment paid |  | 15,000 |  |  |
Verve Therapeutics, Inc. |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Equity securities recognition amount |  | (4,500) | (3,000) |  |
Equity securities |  | $ 3,100 | 7,600 |  |
Verve Therapeutics, Inc. | Common Stock |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Equity shares held |  | 546,970 |  |  |
Prime Medicine Inc |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Equity securities recognition amount |  | $ (9,600) | (15,600) |  |
Equity securities |  | $ 4,700 | $ 14,200 |  |
Prime Medicine Inc | Common Stock |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Equity shares held |  | 1,608,337 | 1,608,337 |  |
Technology Milestones | Guide Therapeutics, Inc. | Maximum | Merger Agreement | Former Stockholders and Optionholders |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Potential milestone payable in form of common stock |  |  |  |  | $ 100,000
Product Milestones | Guide Therapeutics, Inc. | Maximum | Merger Agreement | Former Stockholders and Optionholders |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Potential milestone payable in form of common stock |  |  |  |  | $ 220,000
Development and Regulatory Milestones | Maximum |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Potential milestone payments due under settlement agreement | $ 15,000 |  |  |  |
Sales Milestone | Maximum |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |
Potential milestone payments due under settlement agreement | $ 35,000 |  |  |  |

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