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Nature of the Business and Basis of Presentation - Additional Information (Details) - USD ($)
 1 Months Ended 12 Months Ended 45 Months Ended
Nov. 30, 2023
Oct. 31, 2023
Dec. 31, 2024
Dec. 31, 2024
Dec. 31, 2023
Nature Of Business And Basis Of Presentation [Line Items]          
Accumulated deficit     $ 1,566,631,000 $ 1,566,631,000 $ 1,189,889,000
Cash, cash equivalents, and marketable securities     $ 850,700,000 $ 850,700,000  
Jeffries LLC Sales Agreement          
Nature Of Business And Basis Of Presentation [Line Items]          
Stock sold during period shares, new issues     0 13,769,001  
Gross proceeds from issuance of common stock       $ 864,000,000  
Jeffries LLC Sales Agreement | Common Stock          
Nature Of Business And Basis Of Presentation [Line Items]          
Price per share of shares issued     $ 62.75 $ 62.75  
Jeffries LLC Sales Agreement | Maximum | ATM Offering          
Nature Of Business And Basis Of Presentation [Line Items]          
Commission rate       3.00%  
Aggregate gross proceeds of shares authorized under ATM sales agreement     $ 1,100,000,000 $ 1,100,000,000  
Lilly Agreement          
Nature Of Business And Basis Of Presentation [Line Items]          
Stock purchase agreement amount received   $ 50,000,000      
Collaboration agreement upfront payment received $ 200,000,000        
Sale and issuance of common stock   2,004,811      
Aggregated purchase price   $ 50,000,000      
Lilly Agreement | Maximum          
Nature Of Business And Basis Of Presentation [Line Items]          
Additional proceeds from potential future development-stage payments   $ 350,000,000