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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
ATM Offering
ATM Offering
Common Stock
ATM Offering
Additional Paid-in Capital
Beginning Balance at Dec. 31, 2021 $ 826,738 $ 684 $ 1,594,378 $ (50) $ (768,274)      
Beginning Balance, Shares at Dec. 31, 2021   68,389,425            
Purchase of common stock under ESPP 3,075   3,075          
Purchase of common stock under ESPP, Shares   70,073            
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs           $ 108,076 $ 19 $ 108,057
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares             1,909,103  
Vesting of restricted common stock   $ 4 (4)          
Vesting of restricted common stock, Shares   424,303            
Stock-based compensation 84,321   84,321          
Exercise of common stock options 2,732 $ 5 2,727          
Exercise of common stock options, Shares   484,435            
Other comprehensive income (loss) (2,380)     (2,380)        
Net loss (289,088)       (289,088)      
Ending Balance at Dec. 31, 2022 733,474 $ 712 1,792,554 (2,430) (1,057,362)      
Ending Balance, Shares at Dec. 31, 2022   71,277,339            
Purchase of common stock under ESPP 3,032 $ 1 3,031          
Purchase of common stock under ESPP, Shares   130,403            
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs           $ 235,938 $ 70 $ 235,868
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares             6,952,703  
Issuance of unregistered common shares in connection with license agreement 33,600 $ 20 33,580          
Issuance of unregistered common shares in connection with license agreement, shares   2,004,811            
Vesting of restricted common stock   $ 5 (5)          
Vesting of restricted common stock, Shares   469,531            
Stock-based compensation 98,647   98,647          
Exercise of common stock options 6,131 $ 8 6,123          
Exercise of common stock options, Shares   797,709            
Other comprehensive income (loss) 3,034     3,034        
Net loss (132,527)       (132,527)      
Ending Balance at Dec. 31, 2023 981,329 $ 816 2,169,798 604 (1,189,889)      
Ending Balance, Shares at Dec. 31, 2023   81,632,496            
Purchase of common stock under ESPP 2,621 $ 1 2,620          
Purchase of common stock under ESPP, Shares   135,187            
Vesting of restricted common stock   $ 13 (13)          
Vesting of restricted common stock, Shares   1,302,037            
Stock-based compensation 120,662   120,662          
Exercise of common stock options $ 5,600 $ 6 5,594          
Exercise of common stock options, Shares 563,349 563,349            
Other comprehensive income (loss) $ 75     75        
Net loss (376,742)       (376,742)      
Ending Balance at Dec. 31, 2024 $ 733,545 $ 836 $ 2,298,661 $ 679 $ (1,566,631)      
Ending Balance, Shares at Dec. 31, 2024   83,633,069