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Leases - Additional Information (Details)
$ in Thousands
 1 Months Ended
Aug. 31, 2021
Aug. 31, 2020
USD ($)
ft²
Option
Apr. 30, 2019
USD ($)
Option
Oct. 31, 2018
Option
Feb. 28, 2018
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Lessee Lease Description [Line Items]              
Operating lease right-of-use assets           $ 104,865 $ 112,846
Lease liability           $ 161,425  
Office and Laboratory Space              
Lessee Lease Description [Line Items]              
Operating lease, commencement month and year         2018-03    
Operating lease, termination month and year 2034-02       2029-09    
Operating lease, option to extend     option to extend the lease for two terms of five years each   a term extension option.    
Operating lease, existence of option to extend     true   true    
Operating lease, number of renewal options | Option     2        
Operating lease, option to extend term     5 years        
Leasehold improvements landlord allowance     $ 23,400   $ 6,100    
Office and Laboratory Space | First Phase of Lease in October 2020              
Lessee Lease Description [Line Items]              
Operating lease, commencement month and year     2020-10        
Rent payments beginning month and year     2021-08        
Office and Laboratory Space | Second Phase of Lease in January 2021              
Lessee Lease Description [Line Items]              
Operating lease, commencement month and year     2021-01        
Rent payments beginning month and year     2022-02        
Laboratory Space              
Lessee Lease Description [Line Items]              
Operating lease, commencement month and year       2019-04      
Operating lease, termination month and year       2025-12      
Operating lease, option to extend       The amended lease is subject to fixed-rate rent escalations and provides an option to extend the lease for two additional two-year periods through December 31, 2029.      
Operating lease, existence of option to extend       true      
Operating lease, number of renewal options | Option       2      
Operating lease, option to extend term       2 years      
Manufacturing Facility              
Lessee Lease Description [Line Items]              
Operating lease, commencement month and year   2022-12          
Operating lease, existence of option to extend   true          
Operating lease, number of renewal options | Option   2          
Operating lease, option to extend term   5 years          
Leasehold improvements landlord allowance   $ 20,000          
Manufacturing facility, number of square feet | ft²   100,000          
Operating lease term   15 years          
Lessee operating lease, description   The lease will terminate 15 years from the rent commencement date, December 2022. The lease is subject to fixed-rate rent escalations and provides for $20.0 million in tenant improvements and the option to extend the lease for two terms of five years each, which were not reasonably certain of exercise as of December 31, 2024.