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v3.25.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2025 | Mar. 31, 2024
Operating activities |  |
Net loss | $ (109,270) | $ (98,669)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |
Depreciation and amortization | 5,528 | 5,431
Amortization of investment discount (premiums) | (3,849) | (6,576)
Stock-based compensation expense | 26,682 | 29,281
Change in operating lease right-of-use assets | 2,649 | 2,361
Change in fair value of derivative liabilities | (2,260) | 2,900
Change in fair value of contingent consideration liabilities | 27 | 133
Change in fair value of non-controlling equity investments | 2,081 | 3,353
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | 49 | (5,532)
Accounts payable | 3,793 | 1,285
Accrued expenses and other liabilities | (18,458) | (24,275)
Operating lease liabilities | (3,297) | (3,108)
Deferred revenue | (7,470) | (6,910)
Other long-term liabilities | (89) | 579
Net cash provided by (used in) operating activities | (103,884) | (99,747)
Investing activities |  |
Purchases of property and equipment | (3,065) | (2,438)
Purchases of marketable securities | (339,169) | (195,241)
Maturities of marketable securities | 217,145 | 144,215
Net cash provided by (used in) investing activities | (125,089) | (53,464)
Financing activities |  |
Proceeds from issuance of common shares and pre-funded warrants, net of issuance costs | 471,159 | 0
Proceeds from issuances of stock under ESPP | 1,501 | 1,398
Repayment of equipment financings | 0 | (177)
Proceeds from exercise of stock options | 719 | 1,676
Net cash provided by (used in) financing activities | 473,379 | 2,897
Net change in cash, cash equivalents and restricted cash | 244,406 | (150,314)
Cash, cash equivalents and restricted cash—beginning of period | 290,111 | 444,614
Cash, cash equivalents and restricted cash—end of period | 534,517 | 294,300
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | 0 | 14
Supplemental disclosure of non-cash investing and financing activities: |  |
Property and equipment additions in accounts payable and accrued expenses | 1,455 | 358
Equity issuance costs in accounts payable and accrued expenses | 641 | 0
Operating lease liabilities arising from obtaining right-of-use assets | $ 0 | $ (1,523)

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