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Nature of the Business and Basis of Presentation - Additional Information (Details) - USD ($)
 1 Months Ended 3 Months Ended 48 Months Ended
Mar. 31, 2025
Mar. 31, 2025
Mar. 31, 2024
Mar. 31, 2025
Dec. 31, 2024
Nature Of Business And Basis Of Presentation [Line Items]          
Aggregate net proceeds from offering   $ 471,159,000 $ 0    
Accumulated deficit $ 1,675,901,000 1,675,901,000   $ 1,675,901,000 $ 1,566,631,000
Cash, cash equivalents, and marketable securities $ 1,200,000,000 $ 1,200,000,000   $ 1,200,000,000  
Underwritten Public Offering          
Nature Of Business And Basis Of Presentation [Line Items]          
Stock sold during period shares, new issues 16,151,686        
Price per share of shares issued $ 28.48 $ 28.48   $ 28.48  
Aggregate net proceeds from offering $ 471,200,000        
Legal, accounting and other fees $ 800,000        
Pre-Funded Warrants          
Nature Of Business And Basis Of Presentation [Line Items]          
Warrants to purchase common stock 1,404,988 1,404,988   1,404,988  
Purchase price per warrant $ 28.47        
Jeffries LLC Sales Agreement          
Nature Of Business And Basis Of Presentation [Line Items]          
Stock sold during period shares, new issues   0   13,769,001  
Gross proceeds from issuance of common stock       $ 864,000,000  
Jeffries LLC Sales Agreement | Common Stock          
Nature Of Business And Basis Of Presentation [Line Items]          
Price per share of shares issued $ 62.75 $ 62.75   $ 62.75  
Jeffries LLC Sales Agreement | Maximum | ATM Offering          
Nature Of Business And Basis Of Presentation [Line Items]          
Commission rate       3.00%  
Aggregate gross proceeds of shares authorized under ATM sales agreement $ 1,100,000,000 $ 1,100,000,000   $ 1,100,000,000