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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Operating activities    
Net loss $ (109,270) $ (98,669)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation and amortization 5,528 5,431
Amortization of investment discount (premiums) (3,849) (6,576)
Stock-based compensation expense 26,682 29,281
Change in operating lease right-of-use assets 2,649 2,361
Change in fair value of derivative liabilities (2,260) 2,900
Change in fair value of contingent consideration liabilities 27 133
Change in fair value of non-controlling equity investments 2,081 3,353
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 49 (5,532)
Accounts payable 3,793 1,285
Accrued expenses and other liabilities (18,458) (24,275)
Operating lease liabilities (3,297) (3,108)
Deferred revenue (7,470) (6,910)
Other long-term liabilities (89) 579
Net cash provided by (used in) operating activities (103,884) (99,747)
Investing activities    
Purchases of property and equipment (3,065) (2,438)
Purchases of marketable securities (339,169) (195,241)
Maturities of marketable securities 217,145 144,215
Net cash provided by (used in) investing activities (125,089) (53,464)
Financing activities    
Proceeds from issuance of common shares and pre-funded warrants, net of issuance costs 471,159 0
Proceeds from issuances of stock under ESPP 1,501 1,398
Repayment of equipment financings 0 (177)
Proceeds from exercise of stock options 719 1,676
Net cash provided by (used in) financing activities 473,379 2,897
Net change in cash, cash equivalents and restricted cash 244,406 (150,314)
Cash, cash equivalents and restricted cash—beginning of period 290,111 444,614
Cash, cash equivalents and restricted cash—end of period 534,517 294,300
Supplemental disclosure of cash flow information:    
Cash paid for interest 0 14
Supplemental disclosure of non-cash investing and financing activities:    
Property and equipment additions in accounts payable and accrued expenses 1,455 358
Equity issuance costs in accounts payable and accrued expenses 641 0
Operating lease liabilities arising from obtaining right-of-use assets $ 0 $ (1,523)