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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2023 | $ 981,329 | $ 816 | $ 2,169,798 | $ 604 | $ (1,189,889)
Beginning Balance, Shares at Dec. 31, 2023 |  | 81,632,496 |  |  |
Purchase of common stock under ESPP | 1,398 | $ 1 | 1,397 |  |
Purchase of common stock under ESPP, Shares |  | 76,461 |  |  |
Vesting of restricted common stock |  | $ 4 | (4) |  |
Vesting of restricted common stock, Shares |  | 420,579 |  |  |
Stock-based compensation | 29,281 |  | 29,281 |  |
Exercise of common stock options | 1,676 | $ 2 | 1,674 |  |
Exercise of common stock options, Shares |  | 151,291 |  |  |
Other comprehensive income (loss) | (1,525) |  |  | (1,525) |
Net loss | (98,669) |  |  |  | (98,669)
Ending Balance at Mar. 31, 2024 | 913,490 | $ 823 | 2,202,146 | (921) | (1,288,558)
Ending Balance, Shares at Mar. 31, 2024 |  | 82,280,827 |  |  |
Beginning Balance at Dec. 31, 2023 | 981,329 | $ 816 | 2,169,798 | 604 | (1,189,889)
Beginning Balance, Shares at Dec. 31, 2023 |  | 81,632,496 |  |  |
Net loss | (189,720) |  |  |  |
Ending Balance at Jun. 30, 2024 | 854,094 | $ 824 | 2,233,989 | (1,110) | (1,379,609)
Ending Balance, Shares at Jun. 30, 2024 |  | 82,386,210 |  |  |
Beginning Balance at Mar. 31, 2024 | 913,490 | $ 823 | 2,202,146 | (921) | (1,288,558)
Beginning Balance, Shares at Mar. 31, 2024 |  | 82,280,827 |  |  |
Vesting of restricted common stock |  | $ 1 | (1) |  |
Vesting of restricted common stock, Shares |  | 72,040 |  |  |
Stock-based compensation | 31,604 |  | 31,604 |  |
Exercise of common stock options | 240 |  | 240 |  |
Exercise of common stock options, Shares |  | 33,343 |  |  |
Other comprehensive income (loss) | (189) |  |  | (189) |
Net loss | (91,051) |  |  |  | (91,051)
Ending Balance at Jun. 30, 2024 | 854,094 | $ 824 | 2,233,989 | (1,110) | (1,379,609)
Ending Balance, Shares at Jun. 30, 2024 |  | 82,386,210 |  |  |
Beginning Balance at Dec. 31, 2024 | 733,545 | $ 836 | 2,298,661 | 679 | (1,566,631)
Beginning Balance, Shares at Dec. 31, 2024 |  | 83,633,069 |  |  |
Purchase of common stock under ESPP | 1,501 | $ 1 | 1,500 |  |
Purchase of common stock under ESPP, Shares |  | 90,436 |  |  |
Issuance of common stock and pre-funded warrants, net of issuance costs | 470,478 | $ 162 | 470,316 |  |
Issuance of common stock and pre-funded warrants, net of issuance costs, Shares |  | 16,151,686 |  |  |
Vesting of restricted common stock |  | $ 6 | (6) |  |
Vesting of restricted common stock, Shares |  | 607,196 |  |  |
Stock-based compensation | 26,682 |  | 26,682 |  |
Exercise of common stock options | 719 | $ 1 | 718 |  |
Exercise of common stock options, Shares |  | 74,707 |  |  |
Other comprehensive income (loss) | (519) |  |  | (519) |
Net loss | (109,270) |  |  |  | (109,270)
Ending Balance at Mar. 31, 2025 | 1,123,136 | $ 1,006 | 2,797,871 | 160 | (1,675,901)
Ending Balance, Shares at Mar. 31, 2025 |  | 100,557,094 |  |  |
Beginning Balance at Dec. 31, 2024 | $ 733,545 | $ 836 | 2,298,661 | 679 | (1,566,631)
Beginning Balance, Shares at Dec. 31, 2024 |  | 83,633,069 |  |  |
Exercise of common stock options, Shares | 195,198 |  |  |  |
Net loss | $ (211,561) |  |  |  |
Ending Balance at Jun. 30, 2025 | 1,046,813 | $ 1,008 | 2,823,987 | 10 | (1,778,192)
Ending Balance, Shares at Jun. 30, 2025 |  | 100,758,748 |  |  |
Beginning Balance at Mar. 31, 2025 | 1,123,136 | $ 1,006 | 2,797,871 | 160 | (1,675,901)
Beginning Balance, Shares at Mar. 31, 2025 |  | 100,557,094 |  |  |
Issuance of common stock and pre-funded warrants, net of issuance costs | (4) |  | (4) |  |
Vesting of restricted common stock |  | $ 1 | (1) |  |
Vesting of restricted common stock, Shares |  | 81,163 |  |  |
Stock-based compensation | 24,367 |  | 24,367 |  |
Exercise of common stock options | 1,755 | $ 1 | 1,754 |  |
Exercise of common stock options, Shares |  | 120,491 |  |  |
Other comprehensive income (loss) | (150) |  |  | (150) |
Net loss | (102,291) |  |  |  | (102,291)
Ending Balance at Jun. 30, 2025 | $ 1,046,813 | $ 1,008 | $ 2,823,987 | $ 10 | $ (1,778,192)
Ending Balance, Shares at Jun. 30, 2025 |  | 100,758,748 |  |  |

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