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v3.25.3

Segment Data - Schedule of Reportable Segment Net Revenues and Loss (Details) - USD ($) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
License and collaboration revenue | $ 9,698,000 |  |  | $ 14,269,000 |  |  | $ 25,634,000 | $ 33,451,000
Research and development expenses | 109,769,000 |  |  | 94,258,000 |  |  | 310,343,000 | 266,117,000
General and administrative expenses | 26,740,000 |  |  | 26,515,000 |  |  | 81,539,000 | 82,865,000
Facility and information technology related expenses | 15,116,000 |  |  | 14,568,000 |  |  | 44,076,000 | 42,445,000
Depreciation and amortization | 5,560,000 |  |  | 5,475,000 |  |  | 16,626,000 | 16,482,000
Stock-based compensation | 22,747,000 |  |  | 29,559,000 |  |  | 73,796,000 | 90,444,000
Interest and other income | (10,903,000) |  |  | (12,127,000) |  |  | (33,093,000) | (38,166,000)
Income tax expense |  |  |  |  |  |  | 0 | 39,000
Other segment items | 11,971,000 |  |  | 1,886,000 |  |  | 7,294,000 | 10,435,000
Net loss | (112,728,000) | $ (102,291,000) | $ (109,270,000) | (96,668,000) | $ (91,051,000) | $ (98,669,000) | (324,289,000) | (286,388,000)
External Research And Development Expenses [Member] |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Research and development expenses | 33,565,000 |  |  | 33,420,000 |  |  | 107,879,000 | 82,988,000
External General And Administrative Expenses [Member] |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
General and administrative expenses | 6,589,000 |  |  | 6,078,000 |  |  | 18,265,000 | 18,774,000
Employee Related Expenses [Member] |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Research and development expenses | 27,636,000 |  |  | 23,899,000 |  |  | 84,502,000 | 71,494,000
General and administrative expenses | $ 10,145,000 |  |  | $ 8,179,000 |  |  | $ 30,578,000 | $ 24,904,000

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