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v3.25.3

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Operating activities |  |
Net loss | $ (324,289) | $ (286,388)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |
Depreciation and amortization | 16,626 | 16,482
Amortization of investment discount (premiums) | (12,700) | (18,125)
In-process research and development charge | 14,507 | 0
Stock-based compensation expense | 73,796 | 90,444
Change in operating lease right-of-use assets | 7,870 | 7,193
Change in fair value of derivative liabilities | (650) | (2,400)
Change in fair value of contingent consideration liabilities | (945) | (1,619)
Change in fair value of non-controlling equity investments | (7,271) | 13,003
Realized loss (gain) on sale of marketable securities | 399 | 0
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | 4,452 | 2,458
Accounts payable | 4,846 | 2,357
Accrued expenses and other liabilities | (6,613) | (53,610)
Operating lease liabilities | (10,005) | (9,676)
Deferred revenue | (21,597) | (31,451)
Other long-term liabilities | (239) | 451
Net cash provided by (used in) operating activities | (261,813) | (270,881)
Investing activities |  |
Purchases of property and equipment | (11,212) | (5,976)
Purchases of marketable securities | (848,754) | (486,439)
Maturities of marketable securities | 624,456 | 551,142
Proceeds from sale of marketable securities | 5,743 | 0
Cash paid for acquisition, net | (78) | 0
Net cash provided by (used in) investing activities | (229,845) | 58,727
Financing activities |  |
Proceeds from issuance of common shares and pre-funded warrants, net of issuance costs | 470,513 | 0
Proceeds from issuances of stock under ESPP | 2,764 | 2,622
Repayment of equipment financings | 0 | (485)
Proceeds from exercise of stock options | 2,886 | 2,155
Net cash provided by (used in) financing activities | 476,163 | 4,292
Net change in cash, cash equivalents and restricted cash | (15,495) | (207,862)
Cash, cash equivalents and restricted cash—beginning of period | 290,111 | 444,614
Cash, cash equivalents and restricted cash—end of period | 274,616 | 236,752
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | 0 | 32
Supplemental disclosure of non-cash investing and financing activities: |  |
Property and equipment additions in accounts payable and accrued expenses | 3,126 | 451
Operating lease liabilities arising from obtaining right-of-use assets | 0 | (1,010)
Contingent consideration liabilities assumed in acquisition | 7,715 | 0
Fair value of equity instruments issued in connection with acquisition | $ 6,715 | $ 0

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