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Segment Data - Schedule of Reportable Segment Net Revenues and Loss (Details) - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Segment Reporting Information [Line Items]                
License and collaboration revenue $ 9,698,000     $ 14,269,000     $ 25,634,000 $ 33,451,000
Research and development expenses 109,769,000     94,258,000     310,343,000 266,117,000
General and administrative expenses 26,740,000     26,515,000     81,539,000 82,865,000
Facility and information technology related expenses 15,116,000     14,568,000     44,076,000 42,445,000
Depreciation and amortization 5,560,000     5,475,000     16,626,000 16,482,000
Stock-based compensation 22,747,000     29,559,000     73,796,000 90,444,000
Interest and other income (10,903,000)     (12,127,000)     (33,093,000) (38,166,000)
Income tax expense             0 39,000
Other segment items 11,971,000     1,886,000     7,294,000 10,435,000
Net loss (112,728,000) $ (102,291,000) $ (109,270,000) (96,668,000) $ (91,051,000) $ (98,669,000) (324,289,000) (286,388,000)
External Research And Development Expenses [Member]                
Segment Reporting Information [Line Items]                
Research and development expenses 33,565,000     33,420,000     107,879,000 82,988,000
External General And Administrative Expenses [Member]                
Segment Reporting Information [Line Items]                
General and administrative expenses 6,589,000     6,078,000     18,265,000 18,774,000
Employee Related Expenses [Member]                
Segment Reporting Information [Line Items]                
Research and development expenses 27,636,000     23,899,000     84,502,000 71,494,000
General and administrative expenses $ 10,145,000     $ 8,179,000     $ 30,578,000 $ 24,904,000