<SEC-DOCUMENT>0001072613-25-000167.txt : 20250214
<SEC-HEADER>0001072613-25-000167.hdr.sgml : 20250214
<ACCEPTANCE-DATETIME>20250214165502
ACCESSION NUMBER:		0001072613-25-000167
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250214
DATE AS OF CHANGE:		20250214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Beam Therapeutics Inc.
		CENTRAL INDEX KEY:			0001745999
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91369
		FILM NUMBER:		25630379

	BUSINESS ADDRESS:	
		STREET 1:		26 LANDSDOWNE STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		857-327-8775

	MAIL ADDRESS:	
		STREET 1:		26 LANDSDOWNE STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARCH Venture Fund IX, L.P.
		CENTRAL INDEX KEY:			0001666306
		ORGANIZATION NAME:           	
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		8755 W. HIGGINS ROAD, SUITE 1025
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60631
		BUSINESS PHONE:		773-380-6600

	MAIL ADDRESS:	
		STREET 1:		8755 W. HIGGINS ROAD, SUITE 1025
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60631
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <amendmentNo>3</amendmentNo>
      <securitiesClassTitle>Common Stock par value $0.01 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>12/31/2024</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001745999</issuerCik>
        <issuerName>Beam Therapeutics Inc.</issuerName>
        <issuerCusip>07373V105</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>238 Main Street</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
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        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
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      <reportingPersonName>ARCH Venture Fund IX, L.P.</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
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      <reportingPersonName>ARCH Venture Fund IX Overage, L.P.</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
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      <reportingPersonName>ARCH Venture Partners IX, L.P.</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
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    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>ARCH Venture Partners IX Overage, L.P.</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>4540132.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>4540132.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4540132.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.5</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>ARCH Venture Partners IX, LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>4540132.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>4540132.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4540132.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.5</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Keith Crandell</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>17730.00</soleVotingPower>
        <sharedVotingPower>4540132.00</sharedVotingPower>
        <soleDispositivePower>17730.00</soleDispositivePower>
        <sharedDispositivePower>4540132.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4557862.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.5</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Clinton Bybee</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>10498.00</soleVotingPower>
        <sharedVotingPower>4540132.00</sharedVotingPower>
        <soleDispositivePower>10498.00</soleDispositivePower>
        <sharedDispositivePower>4540132.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4550630.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.5</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Robert Nelsen</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>60615.00</soleVotingPower>
        <sharedVotingPower>4540132.00</sharedVotingPower>
        <soleDispositivePower>60615.00</soleDispositivePower>
        <sharedDispositivePower>4540132.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4600747.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.6</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Beam Therapeutics Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>238 Main Street, Cambridge, MA 02142</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>ARCH Venture Fund IX, L.P. ("AVF IX"); ARCH Venture Partners IX, L.P. ("AVP IX LP"); ARCH Venture Partners IX, LLC ("AVP IX LLC"); ARCH Venture Fund IX Overage, L.P. ("AVF IX Overage"); ARCH Venture Partners IX Overage, L.P. ("AVP IX Overage GP") (collectively, the "Reporting Entities" and individually, each a "Reporting Entity"); and Keith Crandell ("Crandell"), Robert Nelsen ("Nelsen") and Clinton Bybee ("Bybee") (collectively, the "Managing Directors" and individually, each a "Managing Director").  The Reporting Entities and the Managing Directors collectively are referred to as the "Reporting Persons".</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>8755 W. Higgins Avenue, Suite 1025, Chicago, IL 60631</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Each of AVF IX, AVP IX LP, AVF IX Overage and AVP IX Overage GP, are limited partnerships organized under the laws of the State of Delaware. AVP IX LLC is a limited liability company organized under the laws of the State of Delaware.  Each Managing Director is a US citizen.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>AVF IX is the record owner of 2,270,067 shares of Common Stock (the "AVF IX Shares") as of December 31, 2024. AVP IX LP, as the sole general partner of AVF IX, may be deemed to beneficially own the AVF IX Shares.  AVF IX Overage is the record owner of 2,270,065 shares of Common Stock (the "AVF IX Overage Shares"; combined with the AVF IX Shares, the "Record Shares") as of December 31, 2024.  AVP IX Overage GP, as the sole general partner of AVF IX Overage, may be deemed to beneficially own the AVF IX Overage Shares.  AVP IX LLC, as the sole general partner of AVP IX LP and AVP IX Overage GP, may be deemed to beneficially own the Record Shares.  As managing directors of AVP IX LLC, each Managing Director may also be deemed to share the power to direct the disposition and vote of the Record Shares. In addition, as of December 31, 2024, Crandell is a holder of 17,730 Shares of Common Stock, Bybee and his related trusts are the holder of 10,498 shares of Common Stock, and Nelsen and his related trusts are the holder of 60,615 shares of Common Stock.</amountBeneficiallyOwned>
        <classPercent>See line 11 of the cover sheets. The percentages set forth on the cover sheet for each Reporting Person is based upon 82,805,627 shares of common stock outstanding as of October 29, 2024, as reported on the Issuer's Form 10-Q as filed with the Securities and Exchange Commission on November 5, 2024.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>See line 5 of the cover sheets.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>See line 6 of the cover sheets.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>See line 7 of the cover sheets.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>See line 8 of the cover sheets.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
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      <item6>
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      <item8>
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      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
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    <signatureInformation>
      <reportingPersonName>ARCH Venture Fund IX, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>ARCH Venture Partners IX, L.P.</signature>
        <title>its General Partner</title>
        <date>02/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>02/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Fund IX Overage, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>ARCH Venture Partners IX Overage, L.P.</signature>
        <title>its General Partner</title>
        <date>02/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>02/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners IX, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>02/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners IX Overage, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>02/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners IX, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Keith Crandell</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Keith Crandell</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Clinton Bybee</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Clinton Bybee</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Robert Nelsen</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>* Mark McDonnell, as Attorney-in-Fact for Robert Nelsen</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureComments>* This Schedule 13G was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24 to the Form 3 relating to the beneficial ownership of shares of Beam Therapeutics, Inc. by the Reporting Persons filed with the Securities Exchange Commission on February 5, 2020 and incorporated herein in its entirety by reference.</signatureComments>
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<DOCUMENT>
<TYPE>EX-1
<SEQUENCE>2
<FILENAME>exh1_18926.htm
<DESCRIPTION>AGREEMENT
<TEXT>
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     <TITLE></TITLE>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: right"><FONT STYLE="text-transform: uppercase"><B><U>Exhibit
</U></B></FONT><B><U>1</U></B></P>

<P STYLE="font: 11pt Calibri, Helvetica, Sans-Serif; margin: 0; color: #1F497D">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 8pt; text-align: center"><FONT STYLE="font-size: 10pt"><B></B></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 8pt; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>AGREEMENT</U></B></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-indent: 30pt"><FONT STYLE="font-size: 10pt">Pursuant to Rule 13d-1-(k)(1) under the Securities Exchange Act of 1934,
the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to
the ownership by each of the undersigned of shares of stock of Beam Therapeutics, Inc.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-indent: 30pt"><FONT STYLE="font-size: 10pt">This Agreement may be executed in any number
of counterparts, each of which shall be deemed an original.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-size: 10pt">Dated:&#9;&#8239;&#8239;February 14, 2025</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">ARCH VENTURE FUND IX, L.P.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">By: &#8239;&#8239;&#8239;ARCH Venture Partners IX, L.P.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">its General
Partner</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">By: &#8239;&#8239;&#8239;ARCH Venture Partners IX, LLC</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 216pt; text-indent: 10.05pt"><FONT STYLE="font-size: 10pt">its General
Partner</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">By: <U>&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;
&#9;</U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 45.05pt"><FONT STYLE="font-size: 10pt">Keith Crandell&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 45.05pt"><FONT STYLE="font-size: 10pt">Managing
Director</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 45.05pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 372pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt; text-transform: uppercase">ARCH VENTURE PARTNERS IX, L.P.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">By: &#8239;ARCH Venture Partners IX, LLC</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">its General
Partner</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="text-indent: 20pt; font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">By: <U>&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#9;&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;
&#9;</U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Keith Crandell&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Managing
Director</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 372pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">ARCH VENTURE PARTNERS IX, LLC</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">By:&#9;<U>&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#9;&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;
&#9;</U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">Keith Crandell</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">Managing
Director</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT><P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">ARCH VENTURE FUND IX OVERAGE, L.P.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">By: &#8239;&#8239;&#8239;ARCH Venture Partners IX Overage, L.P.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">its General
Partner</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">By: &#8239;&#8239;&#8239;ARCH Venture Partners IX, LLC</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 216pt; text-indent: 10.05pt"><FONT STYLE="font-size: 10pt">its General
Partner</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">By: <U>&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;
&#9;</U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 45.05pt"><FONT STYLE="font-size: 10pt">Keith Crandell&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 45.05pt"><FONT STYLE="font-size: 10pt">Managing
Director</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 203pt; text-indent: 45.05pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 372pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt; text-transform: uppercase">ARCH VENTURE PARTNERS IX OVERAGE, L.P.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">By: &#8239;ARCH Venture Partners IX, LLC</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">its General
Partner</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; text-indent: 20pt; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">By: <U>&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#9;&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;
&#9;</U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Keith Crandell&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Managing
Director</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt; text-indent: 23.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>
</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 107pt; text-indent: 1in"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 107pt; text-indent: 1in"><FONT STYLE="font-size: 10pt"><U>
&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#9;&#9;&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239; </U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">Keith Crandell</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 107pt; text-indent: 1in"><FONT STYLE="font-size: 10pt"><U>
&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#9;&#9;&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239; </U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">Robert Nelsen</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 4.5pt 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 4.5pt 0 180pt"><P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 107pt; text-indent: 1in"><FONT STYLE="font-size: 10pt"><U>&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;*&#9;&#9;&#9;&#9;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239; </U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">Clinton Bybee</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"></P></P>
</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 180pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>
</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 0pt; text-align: justify"><FONT STYLE="font-size: 10pt">* By: <U>&#8239;/s/
Mark McDonnell&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#9;&#9;</U></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 -11pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">Mark
McDonnell as</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 -11pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">Attorney-in-Fact</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 -11pt; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: left"><FONT STYLE="font-size: 10pt">* &#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;&#8239;This Agreement of Joint Filing was executed by Mark McDonnell pursuant
to a Power of Attorney filed as Exhibit 24 to the Form 3 relating to the beneficial ownership of shares of Beam Therapeutics, Inc. by
the Reporting Persons filed with the Securities Exchange Commission on February 5, 2020 and incorporated herein in its entirety by reference.</FONT></P>

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