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STOCK INCENTIVE PLANS (Tables)
3 Months Ended
Mar. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of RSU and PRSU activity
The following table summarizes RSU and PRSU activity during the three months ended March 31, 2018:

Number of
RSUs and PRSUs
Outstanding at December 31, 2017
227,500

RSUs and PRSUs granted
30,000

RSUs and PRSUs vested

RSUs and PRSUs canceled

Outstanding at March 31, 2018
257,500

Summary of Stock Option Activity
The following table summarizes stock option activity during the three months ended March 31, 2018:
 
Number of
Shares
 
Weighted
Average
Exercise Price
 
Weighted
Average
Remaining
Contractual Life
in Years
 
Total Aggregate
Intrinsic Value (in thousands)
Outstanding at December 31, 2017
3,099,173

 
$
7.74

 
8.10
 
$
2,264

Options granted
1,009,250

 
4.29

 
 
 
 
Options exercised
(12,147
)
 
2.29

 
 
 
 
Options canceled
(1,136
)
 
11.14

 
 
 
 
Outstanding at March 31, 2018
4,095,140

 
$
6.90

 
8.38
 
$
837

Vested and expected to vest at March 31, 2018
4,095,140

 
$
6.90

 
8.38
 
$
837

Exercisable at March 31, 2018
1,937,526

 
$
7.42

 
7.45
 
$
746

Schedule of Stock-based Compensation Expense
Stock-based compensation expense recognized for restricted shares, RSUs, PRSUs, stock options, and the ESPP has been reported in the statements of operations as follows (in thousands):
 
Three Months Ended
March 31,
 
2018
 
2017
Research and development
$
640

 
$
432

General and administrative
821

 
619

Total
$
1,461

 
$
1,051