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Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Operating expenses:    
Research and development $ 13,199 $ 10,243
General and administrative 3,611 3,155
Total operating expenses 16,810 13,398
Loss from operations (16,810) (13,398)
Other income:    
Interest income, net 61 0
Total other income 61 0
Net loss (16,749) (13,398)
Other comprehensive loss:    
Unrealized loss on short-term investments (10) (3)
Comprehensive loss $ (16,759) $ (13,401)
Basic and diluted net loss per share (in dollars per share) $ (0.80) $ (0.80)
Shares used to compute basic and diluted net loss per share (in shares) 20,894,353 16,795,366