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Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities |  |  |
Net loss | $ (49,762) | $ (34,495) | $ (41,975)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities |  |  |
Depreciation and amortization | 1,725 | 1,381 | 1,245
Net amortization (accretion) of premiums (discounts) on marketable securities | 1,834 | 578 | (473)
Stock-based compensation | 8,237 | 3,609 | 2,168
Loss on sale of property and equipment | 0 | 2 | 14
Realized gain on marketable securities | 0 | (18) | (8)
Changes in assets and liabilities |  |  |
Accounts receivable | 774 | (1,877) | 0
Prepaid expenses and other assets | (189) | (510) | (1,963)
Right-of-use assets | 1,307 | (148) | 1,093
Accounts payable | 1,166 | 225 | (195)
Accrued and other liabilities | 4,212 | 2,992 | 2,030
Contract liabilities | (23,541) | 83,773 | 0
Lease liabilities | (1,542) | (49) | (1,249)
Net cash provided by (used in) operating activities | (55,779) | 55,463 | (39,313)
Cash flows from investing activities |  |  |
Purchases of property and equipment, net | (2,644) | (493) | (1,353)
Purchases of marketable securities | (314,996) | (242,314) | (88,004)
Maturities of marketable securities | 243,956 | 96,564 | 73,528
Sales of marketable securities | 4,018 | 0 | 18,094
Net cash (used in) provided by investing activities | (69,666) | (146,243) | 2,265
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock in public offering, net of issuance costs | 85,990 | 100,664 | 50,321
Proceeds from issuance of common stock in private placement, net of issuance costs | 0 | 19,988 | 0
Proceeds from issuance of common stock related to at-the-market offering program, net of issuance costs | 57,263 | 6,582 | 0
Proceeds from exercise of common stock options, net of repurchases | 1,504 | 1,190 | 289
Proceeds from ESPP purchases | 697 | 326 | 0
Net cash provided by financing activities | 145,454 | 128,750 | 50,610
Net increase in cash, cash equivalents and restricted cash | 20,009 | 37,970 | 13,562
Cash, cash equivalents and restricted cash, at beginning of period | 72,143 | 34,173 | 20,611
Cash, cash equivalents and restricted cash, at end of period | 92,152 | 72,143 | 34,173
Reconciliation of cash, cash equivalents and restricted cash |  |  |
Cash and cash equivalents | 92,046 | 72,037 | 34,067
Restricted cash | 106 | 106 | 106
Cash, cash equivalents and restricted cash, at end of period | 92,152 | 72,143 | 34,173
Supplemental disclosure of cash flow information: |  |  |
Cash paid for income taxes | 4 | 1 | 1
Cash paid for interest | 71 | 82 | 91
Supplemental non-cash investing and financing activities: |  |  |
Right-of-use asset obtained in exchange for new operating lease liability | 0 | 1,191 | 0
Vesting of early exercised options and restricted stock | 24 | 56 | 114
Purchases of property and equipment in accounts payable and accrued liabilities | 92 | 520 | 0
Conversion of redeemable convertible preferred stock into common stock | $ 0 | $ 0 | $ 138,391

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