XML 72 R59.htm IDEA: XBRL DOCUMENT v3.22.0.1
Subsequent Events - Additional Information (Details)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Jan. 28, 2022
GBP (£)
Jan. 31, 2022
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
shares
Dec. 31, 2020
USD ($)
shares
Dec. 31, 2019
USD ($)
Subsequent Event [Line Items]          
Proceeds from issuance of common stock upon public offering, net of issuance costs | $     $ 85,990 $ 100,664 $ 50,321
Subsequent Event          
Subsequent Event [Line Items]          
Payment of one-time option exercise fee | £ £ 250,000        
Payments for achievement of specific development and regulatory approval events | £ £ 19,500,000        
At The Market Offering | Common Stock          
Subsequent Event [Line Items]          
Issuance of common stock, net of issuance costs, shares | shares     3,407,872 410,896  
At The Market Offering | Subsequent Event | Jefferies LLC | January 2021 Sales Agreement | Common Stock          
Subsequent Event [Line Items]          
Issuance of common stock, net of issuance costs, shares | shares   2,173      
Proceeds from issuance of common stock upon public offering, net of issuance costs | $   $ 50      
Weighted average sales price | $ / shares   $ 24.01