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Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities |  |  |
Net loss | $ (112,961) | $ (58,655) | $ (49,762)
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Depreciation and amortization | 2,476 | 2,101 | 1,725
Net amortization (accretion) of premiums (discounts) on marketable securities | (11,553) | (695) | 1,834
Stock-based compensation | 18,489 | 11,629 | 8,237
Amortization of right of use assets | 1,532 | 1,414 | 1,307
Changes in assets and liabilities |  |  |
Accounts receivable | 193 | 892 | 774
Prepaid expenses and other assets | (2,045) | (2,119) | (189)
Accounts payable | 2,635 | 1,864 | 1,166
Accrued and other liabilities | 1,635 | 4,572 | 4,212
Contract liabilities | (13,753) | (46,479) | (23,541)
Lease liabilities | (1,872) | (1,699) | (1,542)
Net cash used in operating activities | (115,224) | (87,175) | (55,779)
Cash flows from investing activities |  |  |
Purchases of property and equipment, net | (2,368) | (3,443) | (2,644)
Purchases of marketable securities | (595,980) | (255,808) | (314,996)
Maturities of marketable securities | 439,892 | 225,847 | 243,956
Sales of marketable securities | 0 | 0 | 4,018
Net cash used in investing activities | (158,456) | (33,404) | (69,666)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock in public offering, net of issuance costs | 281,165 | 86,105 | 85,990
Proceeds from issuances of pre-funded warrants | 42,182 | 0 | 0
Proceeds from issuance of common stock related to at-the-market offering program, net of issuance costs | 28,598 | 8,857 | 57,263
Proceeds from exercise of common stock options, net of repurchases | 9,559 | 1,448 | 1,504
Proceeds from ESPP purchases | 1,213 | 755 | 697
Net cash provided by financing activities | 362,717 | 97,165 | 145,454
Net increase (decrease) in cash, cash equivalents and restricted cash | 89,037 | (23,414) | 20,009
Cash, cash equivalents and restricted cash, at beginning of period | 68,738 | 92,152 | 72,143
Cash, cash equivalents and restricted cash, at end of period | 157,775 | 68,738 | 92,152
Reconciliation of cash, cash equivalents and restricted cash |  |  |
Cash and cash equivalents | 157,018 | 68,632 | 92,046
Restricted cash | 757 | 106 | 106
Cash, cash equivalents and restricted cash | 157,775 | 68,738 | 92,152
Supplemental disclosure of cash flow information: |  |  |
Cash paid for income taxes | 0 | 0 | 4
Cash paid for interest | 69 | 60 | 71
Supplemental non-cash investing and financing activities: |  |  |
Vesting of early exercised options and restricted stock | 0 | 0 | 24
Purchases of property and equipment in accounts payable and accrued liabilities | 147 | 384 | 92
Right-of-use asset obtained in exchange for a new operating lease liability | 1,294 | 0 | 0
Unpaid offering costs | $ 43 | $ 39 | $ 0

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