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Significant Agreements - Additional Information (Details)
$ in Millions
1 Months Ended
Jul. 31, 2020
USD ($)
Oct. 31, 2023
USD ($)
Apr. 30, 2023
GBP (£)
Aug. 31, 2022
USD ($)
Jul. 31, 2022
Jan. 31, 2022
GBP (£)
Jun. 30, 2020
USD ($)
Sep. 30, 2018
USD ($)
shares
Jun. 30, 2024
USD ($)
shares
Jun. 30, 2024
GBP (£)
shares
Dec. 31, 2023
shares
Aug. 31, 2023
USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Preferred stock, shares issued | shares                 0 0 0  
License Agreement | Novartis International Pharmaceuticals Limited                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Upfront payment               $ 2.5        
License Agreement | Novartis International Pharmaceuticals Limited | Series B Redeemable Convertible Preferred Stock                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Preferred stock, shares issued | shares               263,615        
License Agreement | Cancer Research Technology and the University of Manchester                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Payment of one-time option exercise fee | £           £ 250,000            
Payments for achievement of specific development and regulatory approval events | £           £ 19,500,000            
Milestone payments relating to first and second tumor histologies | £     £ 750,000                  
License Agreement | Amgen Clinical Trial Collaboration and Supply Agreement                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Pay for external third-party cost percentage         50.00%              
Maximum                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Early clinical development milestone payment potential to receive   $ 17.0                    
Maximum | License Agreement | Novartis International Pharmaceuticals Limited                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Certain clinical and regulatory development milestones, agreed to make a payment               $ 9.0        
Certain commercial sales milestones, agreed to make a payment               $ 20.0        
Maximum | License Agreement | Cancer Research Technology and the University of Manchester                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Additional payments for achievement of specific development and regulatory approval events | £                   £ 18,750,000    
Milestone payments of phase two relating to first and second tumor histologies | £                   1,500,000    
Milestone payments of phase two relating to first and second tumor histologies | £                   £ 2.25    
GSK Collaboration Agreement | GSK                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Development and regulatory milestone payment eligible to receive                 $ 13.0      
GSK Collaboration Agreement | GSK | License Agreement                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Upfront payment $ 100.0                      
Number of days of notice period for terminating agreement             90 days          
Pol Theta Program                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Milestone payment received for achievement of initial preclinical development milestone       $ 3.0                
Milestone payment received clinical evaluation                       $ 7.0
Additional payment of development milestone to achieve                 10.0      
Pol Theta Program | Maximum                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Development and regulatory milestone payment eligible to receive             $ 485.0          
Commercial milestone payment eligible to receive             $ 475.0          
Development milestone payment eligible to receive                 $ 465.0      
WRN Program                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Development costs sharing percentage             20.00%          
Milestone payment received for achievement of initial preclinical development milestone   3.0                    
Milestone payment received clinical evaluation   3.0                    
Percentage of profit share             50.00%          
WRN Program | Maximum                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Commercial milestone payment eligible to receive             $ 475.0          
Preclinical development milestone payment potential to receive   7.0                    
Development milestone payment eligible to receive   $ 465.0         $ 485.0          
WRN Program | GSK                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Development costs sharing percentage             80.00%