XML 63 R46.htm IDEA: XBRL DOCUMENT v3.25.0.1
Income Taxes - Additional Information (Details) - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Income Tax Disclosure [Line Items]      
Provision for income taxes $ 0 $ 0 $ 0
Increased valuation allowance 69,000,000 32,100,000 14,200,000
Deferred tax assets, net operating loss carryforwards 37,524,000 34,717,000  
Research and development credit carryforwards 30,868,000 19,997,000  
Penalties or interest accrued 0 0 0
Unrecognized tax benefits 5,927,000 3,822,000 $ 1,962,000
Orphan Drug Credits      
Income Tax Disclosure [Line Items]      
Tax credit carry forward amount 8,100,000 6,300,000  
Federal Income Tax      
Income Tax Disclosure [Line Items]      
Deferred tax assets, net operating loss carryforwards 147,500,000 135,300,000  
Deferred tax assets, operating loss carryforwards subject to expire $ 11,600,000    
Tax credit carry forward expiration year 2037    
Deferred tax assets, operating loss carryforwards subject to do not expire $ 135,900,000    
Research and development credit carryforwards 19,800,000 12,000,000.0  
California State Income Tax      
Income Tax Disclosure [Line Items]      
Deferred tax assets, net operating loss carryforwards 93,500,000 89,600,000  
Deferred tax assets, operating loss carryforwards subject to expire $ 93,500,000    
Tax credit carry forward expiration year 2036    
Research and development credit carryforwards $ 10,800,000 $ 6,400,000  
California      
Income Tax Disclosure [Line Items]      
Tax years 2020 2021