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Significant Agreements - Additional Information (Details) $ in Millions			1 Months Ended
	Jul. 31, 2024 USD ($)	Jul. 31, 2020 USD ($)	Oct. 31, 2023 USD ($)	Apr. 30, 2023 GBP (£)	Aug. 31, 2022 USD ($)	Jul. 31, 2022	Jan. 31, 2022 GBP (£)	Jun. 30, 2020 USD ($)	Sep. 30, 2018 USD ($) shares	Dec. 31, 2024 USD ($) shares	Dec. 31, 2024 GBP (£) shares	Oct. 31, 2024 USD ($)	Dec. 31, 2023 shares	Aug. 31, 2023 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Preferred stock, shares issued | shares										0	0		0
License Agreement | Novartis International Pharmaceuticals Limited
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payment									$ 2.5
License Agreement | Cancer Research Technology and the University of Manchester
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Payment of one-time option exercise fee | £							£ 250,000
Payments for achievement of specific development and regulatory approval events | £							£ 19,500,000
Milestone payments relating to first and second tumor histologies | £				£ 750,000
License Agreement | Amgen Clinical Trial Collaboration and Supply Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Pay for external third-party cost percentage						50.00%
Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Early clinical development milestone payment potential to receive										$ 10.0
Maximum | License Agreement | Novartis International Pharmaceuticals Limited
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Certain clinical and regulatory development milestones, agreed to make a payment									9.0
Certain commercial sales milestones, agreed to make a payment									$ 20.0
Maximum | License Agreement | Cancer Research Technology and the University of Manchester
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Additional payments for achievement of specific development and regulatory approval events | £											£ 18,750,000
Milestone payments of phase two relating to first and second tumor histologies | £											1,500,000
Milestone payments of phase two relating to first and second tumor histologies | £											£ 2.25
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development and regulatory milestone payment eligible to receive	$ 100.0
Payment of option exercise fee	6.5
Total potential milestone payments	$ 400.0
Jiangsu Hengrui Pharmaceuticals Co., Ltd
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development and regulatory milestone payment eligible to receive										200.0
Upfront fee payment										75.0
Totaling milestone payments										1,045.0
Series B Redeemable Convertible Preferred Stock | License Agreement | Novartis International Pharmaceuticals Limited
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Preferred stock, shares issued | shares									263,615
GSK Collaboration Agreement | GSK
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development and regulatory milestone payment eligible to receive										20.0
GSK Collaboration Agreement | GSK | License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payment		$ 100.0
Number of days of notice period for terminating agreement								90 days
Pol Theta Program
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payment received for achievement of initial preclinical development milestone					$ 3.0
Milestone payment received clinical evaluation														$ 7.0
Additional payment of development milestone to achieve										10.0
Pol Theta Program | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development and regulatory milestone payment eligible to receive								$ 485.0
Commercial milestone payment eligible to receive								$ 475.0
Development milestone payment eligible to receive										465.0
WRN Program
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development costs sharing percentage								20.00%
Milestone payment received for achievement of initial preclinical development milestone			$ 3.0
Milestone payment received clinical evaluation												$ 7.0
Percentage of profit share								50.00%
WRN Program | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Commercial milestone payment eligible to receive								$ 475.0
Development milestone payment eligible to receive								$ 485.0		$ 465.0
WRN Program | GSK
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development costs sharing percentage								80.00%

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