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Income Taxes - Reconciliation of Effective Tax Rate to the Statutory Rate (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Amount |  |  |  |  |  |  |  |  |  |  |  |
Income tax (benefit) expense at federal statutory rate |  |  |  |  |  |  |  |  | $ (16,037) | $ (12,192) | $ (4,282) | $ 9,935
State income tax, net of federal benefit |  |  |  |  |  |  |  |  | (2,283) | (1,758) | (1,101) | 1,295
Non-deductible warrants (income)/expense |  |  |  |  |  |  |  |  | 1,360 | (481) | (3,162) | (2,098)
Domestic production activity |  |  |  |  |  |  |  |  | 0 | 0 | 0 | (334)
Other permanent differences |  |  |  |  |  |  |  |  | 106 | 110 | 137 | 191
Research and development tax credits |  |  |  |  |  |  |  |  | (426) | (837) | (1,632) | (1,953)
Tax reserve reassessment |  |  |  |  |  |  |  |  | 104 | (141) | 412 | 246
Federal tax rate change |  |  |  |  |  |  |  |  | 10,899 | 0 | 0 | 0
Change in valuation allowance |  |  |  |  |  |  |  |  | 4,956 | 26,846 | 0 | 0
3PI Settlement |  |  |  |  |  |  |  |  | 1,976 | 0 | 0 | 0
Other, net |  |  |  |  |  |  |  |  | (212) | 66 | (74) | 462
Total tax expense (benefit) | $ (320) | $ 149 | $ 135 | $ 479 | $ (1,238) | $ (1,792) | $ 18,000 | $ (3,357) | $ 443 | $ 11,613 | $ (9,702) | $ 7,744
Percent |  |  |  |  |  |  |  |  |  |  |  |
Income tax (benefit) expense at federal statutory rate |  |  |  |  |  |  |  |  | 34.00% | 34.00% | 34.00% | 34.00%
State income tax, net of federal benefit |  |  |  |  |  |  |  |  | 4.80% | 4.90% | 8.70% | 4.40%
Non-deductible warrants (income)/expense |  |  |  |  |  |  |  |  | (2.90%) | 1.30% | 25.10% | (7.20%)
Domestic production activity |  |  |  |  |  |  |  |  | (0.00%) | (0.00%) | (0.00%) | (1.10%)
Other permanent differences |  |  |  |  |  |  |  |  | (0.20%) | (0.30%) | (1.10%) | 0.70%
Research and development tax credits |  |  |  |  |  |  |  |  | 0.90% | 2.30% | 13.00% | (6.70%)
Tax reserve reassessment |  |  |  |  |  |  |  |  | (0.20%) | 0.40% | (3.30%) | 0.80%
Federal tax rate change |  |  |  |  |  |  |  |  | (23.10%) | 0.00% | 0.00% | 0.00%
Change in valuation allowance |  |  |  |  |  |  |  |  | (10.40%) | (74.90%) | 0.00% | 0.00%
3PI Settlement |  |  |  |  |  |  |  |  | (4.20%) | 0.00% | 0.00% | 0.00%
Other, net |  |  |  |  |  |  |  |  | 0.40% | (0.10%) | 0.60% | 1.60%
Income tax expense (benefit) |  |  |  |  |  |  |  |  | (0.90%) | (32.40%) | 77.00% | 26.50%

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to income tax settlements. Including, but not limited to, domestic tax settlement, foreign tax settlement, state and local tax settlement, and other tax settlements. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32698-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration