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Summary of Significant Accounting Policies - Credit Risk, Restricted Cash, and Allowance for Doubtful Accounts (Details) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 USD ($) Institution | Dec. 31, 2015 USD ($) | Dec. 31, 2014
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Number of major financial institutions with which the company's cash and cash equivalents are deposited | Institution | 1 |  |
Restricted Cash |  |  |
Long term deposit consisting of letter of credit serving as security for lease | $ 603 | $ 603 |
Headquarters and laboratory facilities, South San Francisco, Lease expiring 2016 |  |  |
Restricted Cash |  |  |
Amount held as security for lease | 120 | 118 |
Long term deposit consisting of letter of credit serving as security for lease |  | $ 603 |
Headquarters and laboratory facilities, South San Francisco, Lease signed in April 2015 |  |  |
Restricted Cash |  |  |
Amount held as security for lease | 603 |  |
Long term deposit consisting of letter of credit serving as security for lease | $ 603 |  |
Revenue | Revenue concentration risk |  |  |
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Concentrations of credit risk (as a percent) | 47.00% | 49.00% | 55.00%
Revenue | Revenue concentration risk | Medicare |  |  |
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Concentrations of credit risk (as a percent) | 27.00% | 26.00% | 26.00%
Revenue | Revenue concentration risk | United Healthcare |  |  |
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Concentrations of credit risk (as a percent) | 12.00% | 14.00% | 18.00%
Revenue | Revenue concentration risk | Aetna |  |  |
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Concentrations of credit risk (as a percent) | 8.00% | 9.00% | 11.00%
Accounts receivable | Gross receivables concentration risk | Medicare |  |  |
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Concentrations of credit risk (as a percent) | 18.00% | 31.00% |
Accounts receivable | Gross receivables concentration risk | United Healthcare |  |  |
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Concentrations of credit risk (as a percent) | 8.00% | 25.00% |
Accounts receivable | Gross receivables concentration risk | Aetna |  |  |
Concentrations of Credit Risk and Other Risks and Uncertainties |  |  |
Concentrations of credit risk (as a percent) | 4.00% | 23.00% |

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