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Genzyme Co-promotion Agreement (Details) $ in Thousands |  |  | 1 Months Ended | 12 Months Ended | 14 Months Ended | 22 Months Ended | 31 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 01, 2015 | Aug. 12, 2014 | Feb. 29, 2012 USD ($) | Feb. 29, 2008 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2012 | Feb. 27, 2014 | Dec. 31, 2015 USD ($) | Aug. 11, 2014 | Feb. 28, 2015 country | Jan. 31, 2012 country
Genzyme Co-promotion Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization of up-front co-promotion fee |  |  |  |  | $ 948 | $ 1,897 | $ 2,269 |  |  |  |  |  |
Co-promotion agreement | Genzyme |  |  |  |  |  |  |  |  |  |  |  |  |
Genzyme Co-promotion Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Co-promotion expenses |  |  |  |  | 6,100 | 7,300 | 12,000 |  |  |  |  |  |
Outstanding obligation to Genzyme |  |  |  |  | 0 | 2,100 |  |  |  | $ 2,100 |  |  |
Amortization of up-front co-promotion fee |  |  |  |  | $ 900 | $ 1,900 | $ 2,300 |  |  |  |  |  |
Afirma thyroid diagnostic solution co-promotion agreement | Genzyme |  |  |  |  |  |  |  |  |  |  |  |  |
Genzyme Co-promotion Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Number of countries outside United States for exclusive promotion under the agreement | country |  |  |  |  |  |  |  |  |  |  |  |  | 40
Co-promotion fee received from Genzyme |  |  | $ 10,000 | $ 10,000 |  |  |  |  |  |  |  |  |
Co-promotion fees as a percentage of cash receipts |  |  |  |  | 15.00% |  |  | 50.00% | 40.00% | 32.00% |  |  |
Straight-line amortization period of co-promotion fee |  |  |  |  |  |  |  |  |  |  | 4 years |  |
Termination notification period |  | 6 months |  |  |  |  |  |  |  |  |  |  |
Ex-U.S. Co-Promotion Agreement | Genzyme |  |  |  |  |  |  |  |  |  |  |  |  |
Genzyme Co-promotion Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Number of countries outside United States for exclusive promotion under the agreement | country |  |  |  |  |  |  |  |  |  |  |  | 5 |
Co-promotion fee paid as a percentage of net revenue | 25.00% |  |  |  |  |  |  |  |  |  |  |  |
Period of agreement | 5 years |  |  |  |  |  |  |  |  |  |  |  |

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