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Summary of Significant Accounting Policies - Liquidity (Details) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Mar. 30, 2016 | Nov. 30, 2016 | Apr. 30, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Liquidity |  |  |  |  |  |  |
Accumulated deficit |  |  |  | $ 180,084 | $ 148,726 |  |
Cash and cash equivalents |  |  |  | $ 59,219 | $ 39,084 | $ 35,014 | $ 71,220
Common stock, shares issued |  |  |  | 33,762,278 | 27,685,291 |  |
Repayments of long-term debt |  |  |  | $ 5,000 | $ 0 | 0 |
Net proceeds from sale of common stock in private placement |  |  |  | $ 0 | $ 37,258 | $ 0 |
Common Stock |  |  |  |  |  |  |
Liquidity |  |  |  |  |  |  |
Common stock, shares issued |  | 5,723,300 |  |  |  |  |
Shares issued, price per share (in usd per share) |  | $ 6.00 |  |  |  |  |
Proceeds from issuance of common stock |  | $ 32,100 |  |  |  |  |
Payments of stock issuance costs |  | $ 2,200 |  |  |  |  |
Number of common stock issued and sold in private placement |  |  |  | 5,723,300 | 4,907,975 |  |
Share Price (in usd per share) |  |  |  | $ 7.74 | $ 7.20 |  |
Common Stock | Private placement |  |  |  |  |  |  |
Liquidity |  |  |  |  |  |  |
Number of common stock issued and sold in private placement |  |  | 4,907,975 |  |  |  |
Share Price (in usd per share) |  |  | $ 8.15 |  |  |  |
Net proceeds from sale of common stock in private placement |  |  | $ 37,300 |  |  |  |
Agent fees and other expenses |  |  | $ 2,700 |  |  |  |
Line of Credit | Visium | Initial Term Loan |  |  |  |  |  |  |
Liquidity |  |  |  |  |  |  |
Proceeds from lines of credit | $ 25,000 |  |  |  |  |  |
Repayments of long-term debt | $ 5,000 |  |  |  |  |  |

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