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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2016
Income Tax Disclosure [Abstract] |
Schedule of reconciliation of tax expense computed at the statutory federal rate and the Company's tax expense | The following table presents a reconciliation of the tax expense computed at the statutory federal rate and the Company's tax expense for the periods presented (in thousands of dollars):
| Year Ended December, 31,
| 2016 |  | 2015 |  | 2014
U.S. federal taxes at statutory rate | $ | (10,662 | ) |  | $ | (11,459 | ) |  | $ | (9,987 | )
State tax (net of federal benefit) | 20 |  |  | (30 | ) |  | 5 |
Permanent differences | 153 |  |  | 96 |  |  | 64 |
Incentive stock options | 1,095 |  |  | 789 |  |  | 672 |
Tax credits | (677 | ) |  | (581 | ) |  | (461 | )
Change in valuation allowance | 10,071 |  |  | 11,185 |  |  | 9,707 |
Total | $ | — |  |  | $ | — |  |  | $ | — |
Schedule of significant components of the Company's deferred tax assets and liabilities | Significant components of the Company's deferred tax assets and liabilities are as follows (in thousands of dollars):
| Year Ended December 31,
| 2016 |  | 2015 |  | 2014
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards | $ | 61,674 |  |  | $ | 52,262 |  |  | $ | 41,971 |
Research and development credits | 3,174 |  |  | 2,497 |  |  | 1,916 |
Stock-based compensation | 2,847 |  |  | 1,825 |  |  | 826 |
Genzyme co-promotion agreement | — |  |  | 330 |  |  | 995 |
Accruals, deferred rent and other | 4,511 |  |  | 4,698 |  |  | 3,381 |
Gross deferred tax assets | 72,206 |  |  | 61,612 |  |  | 49,089 |
Valuation allowance | (65,975 | ) |  | (55,101 | ) |  | (43,439 | )
Net deferred tax assets | 6,231 |  |  | 6,511 |  |  | 5,650 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Property and equipment | (1,180 | ) |  | (1,215 | ) |  | (60 | )
In-process research and development | (5,051 | ) |  | (5,296 | ) |  | (5,590 | )
Gross deferred tax liabilities | (6,231 | ) |  | (6,511 | ) |  | (5,650 | )
Net deferred tax liabilities | (6,231 | ) |  | (6,511 | ) |  | (5,650 | )
Net deferred taxes | $ | — |  |  | $ | — |  |  | $ | — |
Schedule of reconciliation of the beginning and ending amount of unrecognized tax benefits | A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands of dollars):
| Year Ended December 31,
| 2016 |  | 2015 |  | 2014
Unrecognized tax benefits, beginning of period | $ | 1,871 |  |  | $ | 1,571 |  |  | $ | 727 |
Gross increases—tax position in prior period | — |  |  | — |  |  | 548 |
Gross decreases—tax position in prior period | — |  |  | — |  |  | — |
Gross increases—current period tax position | 351 |  |  | 300 |  |  | 296 |
Lapse of statute of limitations | — |  |  | — |  |  | — |
Unrecognized tax benefits, end of period | $ | 2,222 |  |  | $ | 1,871 |  |  | $ | 1,571 |

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