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Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating activities |  |  |
Net loss | $ (31,358) | $ (33,704) | $ (29,373)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 3,511 | 2,254 | 1,175
Bad debt expense | 68 | 105 | 54
Loss on disposal of property and equipment | 12 | 0 | 0
Genzyme co-promotion fee amortization | (948) | (1,897) | (2,269)
Stock-based compensation | 6,378 | 5,602 | 3,548
Conversion of accrued interest to long-term debt | 385 | 0 | 0
Amortization of debt discount and issuance costs | 173 | 46 | 97
Interest on debt balloon payment and prepayment penalty | 206 | 79 | 81
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (5,321) | (558) | (1,961)
Supplies inventory | 292 | (71) | (1,129)
Prepaid expenses and current other assets | (415) | 304 | (38)
Other assets | 25 | (42) | (46)
Accounts payable | (1,441) | (3,546) | 1,874
Accrued liabilities and deferred rent | 451 | 4,463 | 355
Net cash used in operating activities | (27,982) | (26,965) | (27,632)
Investing activities |  |  |
Purchases of property and equipment | (4,210) | (6,165) | (2,024)
Cash remitted for acquisition, net of cash received | 0 | 0 | (6,916)
Change in restricted cash | (2) | (533) | (70)
Net cash used in investing activities | (4,212) | (6,698) | (9,010)
Financing activities |  |  |
Proceeds from the issuance of long-term debt, net of debt issuance costs | 24,452 | 0 | 0
Proceeds from issuance of common stock in a private placement, net of issuance costs | 0 | 37,258 | 0
Proceeds from issuance of common stock in a public offering, net of issuance costs | 31,949 |  |
Commissions and issuance costs relating to initial public offering | 0 | 0 | (129)
Payment of long-term debt | (5,000) | 0 | 0
Payment of end-of-term debt obligation and prepayment penalty | (288) | 0 | (110)
Payment of deferred stock offering costs | 0 | (247) | 0
Proceeds from the exercise of common stock options and employee stock purchases | 1,216 | 722 | 675
Net cash provided by financing activities | 52,329 | 37,733 | 436
Net increase (decrease) in cash and cash equivalents | 20,135 | 4,070 | (36,206)
Cash and cash equivalents at beginning of period | 39,084 | 35,014 | 71,220
Cash and cash equivalents at end of period | 59,219 | 39,084 | 35,014
Supplementary cash flow information of non-cash investing and financing activities: |  |  |
Fair value of common stock issued for acquisition | 0 | 0 | 10,078
Non-cash issuance of long-term debt | 0 | 0 | 5,000
Non-cash repayment of long-term debt | 0 | 0 | (5,000)
Net receivable for reimbursement of public offering issuance costs | 144 | 0 | 0
Purchases of property and equipment included in accounts payable and accrued liabilities | 363 | 1,825 | 383
Issuance of common stock from the non-cash exercise of common stock warrants | 0 | 0 | 187
Supplementary cash flow information: |  |  |
Cash paid for interest on debt | 2,149 | 278 | 307
Cash paid for tax | $ 7 | $ 22 | $ 0

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- Definition Amount of expense related to write-down of receivables to the amount expected to be collected. Includes, but is not limited to, accounts receivable and notes receivable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.5) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition The amount of previously reported deferred or unearned revenue that was recognized as revenue during the period. For cash flows, this element primarily pertains to amortization of deferred credits on long-term arrangements. As a noncash item, it is deducted from net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 13.A.3) -URI http://asc.fasb.org/extlink&oid=65893310&loc=d3e214044-122780 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 13.A.4) -URI http://asc.fasb.org/extlink&oid=65893310&loc=d3e214044-122780 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition Value of stock issued pursuant to acquisitions during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.29-31) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Represents the amount of interest end of term payment of debt. + References No definition available. + Details
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- Definition The increase (decrease) during the reporting period in the amount of expenses incurred but not yet paid and deferred rent. + References No definition available. + Details
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- Definition The cash outflow for the payment of the end-of-term obligation and prepayment penalty. + References No definition available. + Details
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- Definition The cash outflow of deferred stock offering costs incurred directly with the issuance of an equity security. + References No definition available. + Details
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- Definition The cash outflow for cost incurred directly with the issuance of an equity security in an initial public offering. + References No definition available. + Details
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- Definition The fair value of stock issued in noncash exercise of common stock warrants. + References No definition available. + Details
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