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Summary of Significant Accounting Policies - Liquidity (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Mar. 30, 2016
Nov. 30, 2016
Apr. 30, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Liquidity              
Accumulated deficit       $ 180,084 $ 148,726    
Cash and cash equivalents       $ 59,219 $ 39,084 $ 35,014 $ 71,220
Common stock, shares issued       33,762,278 27,685,291    
Repayments of long-term debt       $ 5,000 $ 0 0  
Net proceeds from sale of common stock in private placement       $ 0 $ 37,258 $ 0  
Common Stock              
Liquidity              
Common stock, shares issued   5,723,300          
Shares issued, price per share (in usd per share)   $ 6.00          
Proceeds from issuance of common stock   $ 32,100          
Payments of stock issuance costs   $ 2,200          
Number of common stock issued and sold in private placement       5,723,300 4,907,975    
Share Price (in usd per share)       $ 7.74 $ 7.20    
Common Stock | Private placement              
Liquidity              
Number of common stock issued and sold in private placement     4,907,975        
Share Price (in usd per share)     $ 8.15        
Net proceeds from sale of common stock in private placement     $ 37,300        
Agent fees and other expenses     $ 2,700        
Line of Credit | Visium | Initial Term Loan              
Liquidity              
Proceeds from lines of credit $ 25,000            
Repayments of long-term debt $ 5,000