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v3.8.0.1

Condensed Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2017 | Sep. 30, 2016
Operating activities |  |
Net loss | $ (22,564) | $ (26,955)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 2,839 | 2,602
Bad debt expense | 0 | 68
Loss on disposal of property and equipment | 0 | 12
Genzyme co-promotion fee amortization | 0 | (948)
Stock-based compensation | 4,825 | 4,745
Conversion of accrued interest on long-term debt | 0 | 385
Amortization and write-off of debt discount and issuance costs | 79 | 146
Interest on debt balloon payment and prepayment penalty | 0 | 206
Changes in operating assets and liabilities: |  |
Accounts receivable | (2,879) | (2,877)
Supplies inventory | (285) | 351
Prepaid expenses and current other assets | 240 | 37
Other assets | (44) | (44)
Accounts payable | 891 | (387)
Accrued liabilities and deferred rent | (1,201) | (1,091)
Net cash used in operating activities | (18,099) | (23,750)
Investing activities |  |
Purchases of property and equipment | (1,455) | (3,760)
Proceeds from sale of property and equipment | 440 | 0
Change in restricted cash | 120 | (2)
Net cash used in investing activities | (895) | (3,762)
Financing activities |  |
Proceeds from the issuance of long-term debt, net of debt issuance costs | 0 | 24,452
Payment of long-term debt | 0 | (5,000)
Payment of end-of-term debt obligation and prepayment penalty | 0 | (288)
Proceeds from the issuance of common stock in a public offering, net of costs | 200 | 0
Payment of capital lease liability | (204) | 0
Proceeds from the exercise of common stock options and employee stock purchases | 974 | 963
Net cash provided by financing activities | 970 | 20,127
Net decrease in cash and cash equivalents | (18,024) | (7,385)
Cash and cash equivalents at beginning of period | 59,219 | 39,084
Cash and cash equivalents at end of period | 41,195 | 31,699
Supplementary cash flow information of non-cash investing and financing activities: |  |
Purchases of property and equipment included in accounts payable and accrued liabilities | $ 188 | $ 0

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